A collaborative framework for human missing protein data sharing…
image source:http://filthy-frank.wikia.com/wiki/Chromosomes?file=Chromosome.jpg
brief information
The MissingProteinPedia is a protein data and information sharing web system that aims to collate any relevant data ‘Missing proteins’ as defined by neXtProt. At its core is a schema-less database-driven web system allowing captures of all PE2-4 protein PubMed data, based on gene and protein including synonyms. The database also allows unpublished, preliminary or proprietary data (e.g., antibody, MS, cell biological and genetic studies) to be shared with collaborators via a protected interface.
MissingProteinPedia facilitates the Human Proteome Project (HPP) cross-disciplinary collaboration by providing a complimentary, unfiltered, lower stringency perspective to both the HPP metrics and guidelines approaches, enabling community evaluation and scrutiny. MissingProteinPedia incorporates text mining technology to fetch and search accumulated UniProt, GeneCards, GeneRifs, PubMed PE2-4 data. Besides, MissingProteinPedia summarizes publicly available MS data from PRIDE, GPMDB, ProteomicsDB and MaxQB for relevant PE2-4 proteins. It allows community administrators to curate information before web publication.
We encourage all visitors to browse and contribute to 'finding' these proteins by sharing any relevant information on them that we may have missed!
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list of proteins
| Protein ID | Gene ID | Protein Name | Chromosome ID | Gene Name | Tag(s) | |
|---|---|---|---|---|---|---|
| O00270 | GPR31 | 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor | Chromosome-6 | 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor | ||
| Q96PD6 | MOGAT1 | 2-acylglycerol O-acyltransferase 1 | Chromosome-2 | 2-acylglycerol O-acyltransferase 1 | ||
| Q96P68 | OXGR1 | 2-oxoglutarate receptor 1 | Chromosome-13 | 2-oxoglutarate receptor 1 | ||
| Q8TD47 | RPS4Y2 | 40S ribosomal protein S4, Y isoform 2 | Chromosome-Y | 40S ribosomal protein S4, Y isoform 2 | ||
| P30939 | HTR1F | 5-hydroxytryptamine receptor 1F | Chromosome-3 | 5-hydroxytryptamine receptor 1F | ||
| P47898 | HTR5A | 5-hydroxytryptamine receptor 5A | Chromosome-7 | 5-hydroxytryptamine receptor 5A | ||
| Q8TE56 | ADAMTS17 | A disintegrin and metalloproteinase with thrombospondin motifs 17 | Chromosome-15 | A disintegrin and metalloproteinase with thrombospondin motifs 17 | ||
| Q8TE59 | ADAMTS19 | A disintegrin and metalloproteinase with thrombospondin motifs 19 | Chromosome-5 | A disintegrin and metalloproteinase with thrombospondin motifs 19 | ||
| P59510 | ADAMTS20 | A disintegrin and metalloproteinase with thrombospondin motifs 20 | Chromosome-12 | A disintegrin and metalloproteinase with thrombospondin motifs 20 | ||
| Q9UKP5 | ADAMTS6 | A disintegrin and metalloproteinase with thrombospondin motifs 6 | Chromosome-5 | A disintegrin and metalloproteinase with thrombospondin motifs 6 | ||
| Q7Z5M8 | ABHD12B | Abhydrolase domain-containing protein 12B | Chromosome-14 | Abhydrolase domain-containing protein 12B | ||
| Q9H3Z7 | ABHD16B | Abhydrolase domain-containing protein 16B | Chromosome-20 | Abhydrolase domain-containing protein 16B | ||
| Q9NQ33 | ASCL3 | Achaete-scute homolog 3 | Chromosome-11 | Achaete-scute homolog 3 | ||
| Q8N0Z2 | ABRA | Actin-binding Rho-activating protein | Chromosome-8 | Actin-binding Rho-activating protein | ||
| Q9C0K3 | ACTR3C | Actin-related protein 3C | Chromosome-7 | Actin-related protein 3C | ||
| Q7LC44 | ARC | Activity-regulated cytoskeleton-associated protein | Chromosome-8 | Activity-regulated cytoskeleton-associated protein | ||
| Q9NUZ1 | ACOXL | Acyl-coenzyme A oxidase-like protein | Chromosome-2 | Acyl-coenzyme A oxidase-like protein | ||
| P0C7M7 | ACSM4 | Acyl-coenzyme A synthetase ACSM4, mitochondrial | Chromosome-12 | Acyl-coenzyme A synthetase ACSM4, mitochondrial | ||
| P29275 | ADORA2B | Adenosine receptor A2b | Chromosome-17 | Adenosine receptor A2b | ||
| P0DMS8 | ADORA3 | Adenosine receptor A3 | Chromosome-1 | Adenosine receptor A3 |
Publications to be cited for using MPP data and services
| Islam, M.T. et al. Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the “Missing” Human Proteome. Journal of Proteome Research 13 (1), 76-83, doi: 10.1021/pr400794x (2014) |
| Islam, M.T. et al. A systematic bioinformatics approach to identify high quality MS data and functionally annotate proteins and proteomes. Methods Mol. Biol.1549, 163–176, doi: 10.1007/978-1-4939-6740-7_13 (2016) |
| Baker, M. S. et al. Accelerating the search for the missing proteins in the human proteome. Nat. Commun. 8, 14271 doi: 10.1038/ncomms14271 (2017). |
| Islam, M.T. et al. Missing ProteinPedia - under preparation. |
All to contact us
Professor Mark S. Baker
Professor Shoba Ranganathan