A collaborative framework for human missing protein data sharing…
image source:http://filthy-frank.wikia.com/wiki/Chromosomes?file=Chromosome.jpg
brief information
The MissingProteinPedia is a protein data and information sharing web system that aims to collate any relevant data ‘Missing proteins’ as defined by neXtProt. At its core is a schema-less database-driven web system allowing captures of all PE2-4 protein PubMed data, based on gene and protein including synonyms. The database also allows unpublished, preliminary or proprietary data (e.g., antibody, MS, cell biological and genetic studies) to be shared with collaborators via a protected interface.
MissingProteinPedia facilitates the Human Proteome Project (HPP) cross-disciplinary collaboration by providing a complimentary, unfiltered, lower stringency perspective to both the HPP metrics and guidelines approaches, enabling community evaluation and scrutiny. MissingProteinPedia incorporates text mining technology to fetch and search accumulated UniProt, GeneCards, GeneRifs, PubMed PE2-4 data. Besides, MissingProteinPedia summarizes publicly available MS data from PRIDE, GPMDB, ProteomicsDB and MaxQB for relevant PE2-4 proteins. It allows community administrators to curate information before web publication.
We encourage all visitors to browse and contribute to 'finding' these proteins by sharing any relevant information on them that we may have missed!
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list of proteins
| Protein ID | Gene ID | Protein Name | Chromosome ID | Gene Name | Tag(s) | |
|---|---|---|---|---|---|---|
| Q9BXT5 | TEX15 | Testis-expressed sequence 15 protein | Chromosome-8 | Testis-expressed sequence 15 protein | ||
| Q50LG9 | LRRC24 | Leucine-rich repeat-containing protein 24 | Chromosome-8 | Leucine-rich repeat-containing protein 24 | ||
| Q30KP9 | DEFB135 | Beta-defensin 135 | Chromosome-8 | Beta-defensin 135 | ||
| Q30KP8 | DEFB136 | Beta-defensin 136 | Chromosome-8 | Beta-defensin 136 | ||
| Q7LC44 | ARC | Activity-regulated cytoskeleton-associated protein | Chromosome-8 | Activity-regulated cytoskeleton-associated protein | ||
| Q6ZMY9 | ZNF517 | Zinc finger protein 517 | Chromosome-8 | Zinc finger protein 517 | ||
| Q08648 | SPAG11B | Sperm-associated antigen 11B | Chromosome-8 | Sperm-associated antigen 11B | ||
| Q05901 | CHRNB3 | Neuronal acetylcholine receptor subunit beta-3 | Chromosome-8 | Neuronal acetylcholine receptor subunit beta-3 | ||
| Q8N0Z2 | ABRA | Actin-binding Rho-activating protein | Chromosome-8 | Actin-binding Rho-activating protein | ||
| Q8NHS2 | GOT1L1 | Putative aspartate aminotransferase, cytoplasmic 2 | Chromosome-8 | Putative aspartate aminotransferase, cytoplasmic 2 | ||
| O95214 | LEPROTL1 | Leptin receptor overlapping transcript-like 1 | Chromosome-8 | Leptin receptor overlapping transcript-like 1 | ||
| Q9HAK2 | EBF2 | Transcription factor COE2 | Chromosome-8 | Transcription factor COE2 | ||
| Q5PT55 | SLC10A5 | Sodium/bile acid cotransporter 5 | Chromosome-8 | Sodium/bile acid cotransporter 5 | ||
| Q6UXT8 | FAM150A | Protein FAM150A | Chromosome-8 | Protein FAM150A | ||
| Q5GH73 | XKR6 | XK-related protein 6 | Chromosome-8 | XK-related protein 6 | ||
| Q9BYZ6 | RHOBTB2 | Rho-related BTB domain-containing protein 2 | Chromosome-8 | Rho-related BTB domain-containing protein 2 | ||
| Q02509 | OC90 | Otoconin-90 | Chromosome-8 | Otoconin-90 | ||
| Q6UXB3 | LYPD2 | Ly6/PLAUR domain-containing protein 2 | Chromosome-8 | Ly6/PLAUR domain-containing protein 2 | ||
| Q8IX29 | FBXO16 | F-box only protein 16 | Chromosome-8 | F-box only protein 16 | ||
| C9JL84 | HHLA1 | HERV-H LTR-associating protein 1 | Chromosome-8 | HERV-H LTR-associating protein 1 |
Publications to be cited for using MPP data and services
| Islam, M.T. et al. Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the “Missing” Human Proteome. Journal of Proteome Research 13 (1), 76-83, doi: 10.1021/pr400794x (2014) |
| Islam, M.T. et al. A systematic bioinformatics approach to identify high quality MS data and functionally annotate proteins and proteomes. Methods Mol. Biol.1549, 163–176, doi: 10.1007/978-1-4939-6740-7_13 (2016) |
| Baker, M. S. et al. Accelerating the search for the missing proteins in the human proteome. Nat. Commun. 8, 14271 doi: 10.1038/ncomms14271 (2017). |
| Islam, M.T. et al. Missing ProteinPedia - under preparation. |
All to contact us
Professor Mark S. Baker
Professor Shoba Ranganathan