ASCL3:Achaete-scute homolog 3

Gene Name
Achaete-scute homolog 3
Protein ID
Q9NQ33
Chromosome ID
11
HPP Status
2
Protein Name
Achaete-scute homolog 3
Synonyms

achaete-scute homolog 3

HASH3

achaete-scute complex homolog 3 (Drosophila)

BHLHA42

achaete-scute complex (Drosophila) homolog-like 3

bHLH transcriptional regulator Sgn-1

achaete-scute complex homolog 3

bHLH transcription factor Sgn-1 (Salivary Glands 1)

achaete-scute family bHLH transcription factor 3

class A basic helix-loop-helix protein 42

ASH-3

hASH3

Class A basic helix-loop-helix protein 42

bHLHa42

SGN1


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ASCL3 ]
Chromosomal Position
11p15.4 | Start:8937579 End:8937579
Sequence
Q9NQ33.fasta
Description

Entrez Gene Summary for ASCL3
Basic helix-loop-helix transcription factors, such as ASCL3, are essential for the determination of cell fate and the development and differentiation of numerous tissues (Jonsson et al., 2004 (PubMed 15475265)).(supplied by OMIM, Mar 2008)

UniProtKB Summary for ASCL3
Function: Transcriptional repressor. Inhibits myogenesis (By similarity)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ASCL3 ]
External IDs
Hgnc ID: 740 EntrezGene ID: 56676 Ensembl ID: ENSG00000176009
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ASCL3 ]
Reference Source
http://www.nextprot.org

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidenceASCL3_HUMANPTF1A_RAT1805451.8530260981511682217.00E-1060
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
ASCL3_HUMANIPR011598GO:0046983DomainMyc-type, basic helix-loop-helix (bHLH) domainMolecular Functionprotein dimerization activity
ASCL3_HUMANIPR015660GO:0003677FamilyAchaete-scute transcription factor-relatedMolecular FunctionDNA binding
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/Q9NQ33_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/Q9NQ33_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Proteomics DB

Evidence File
/mnt/mpp/ms_data/Q9NQ33_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB