DBX1:Homeobox protein DBX1

Gene Name
Homeobox protein DBX1
Protein ID
A6NMT0
Chromosome ID
11
HPP Status
3
Protein Name
Homeobox protein DBX1
Synonyms

developing brain homeobox protein 1

homeobox protein DBX1

Developing brain homeobox protein 1

developing brain homeobox 1


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=DBX1 ]
Chromosomal Position
11p15.1 | Start:20156155 End:20156155
Sequence
A6NMT0.fasta
Description

UniProtKB Summary for DBX1
Function: Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons (By similarity)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=DBX1 ]
External IDs
Hgnc ID: 33185 EntrezGene ID: 120237 Ensembl ID: ENSG00000109851
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=DBX1 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
21048147Dbx1-derived neurons are essential for the transgenic expression and generation of respiratory behavior both in vitro and in vivo.2010-12-11
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidenceDBX1_HUMANNKX32_MOUSE343685019.833021772442032662.00E-1063
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
DBX1_HUMANIPR000047GO:0000976Conserved_siteHelix-turn-helix motifMolecular Functiontranscription regulatory region sequence-specific DNA binding
DBX1_HUMANIPR001356GO:0003700DomainHomeobox domainMolecular Functionsequence-specific DNA binding transcription factor activity
DBX1_HUMANIPR001356GO:0043565DomainHomeobox domainMolecular Functionsequence-specific DNA binding
DBX1_HUMANIPR009057GO:0003677DomainHomeodomain-likeMolecular FunctionDNA binding
DBX1_HUMANIPR017970GO:0005634Conserved_siteHomeobox, conserved siteCellular Componentnucleus
DBX1_HUMANIPR017970GO:0043565Conserved_siteHomeobox, conserved siteMolecular Functionsequence-specific DNA binding
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/A6NMT0_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/A6NMT0_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Proteomics DB

Evidence File
/mnt/mpp/ms_data/A6NMT0_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB