TRIM66:Tripartite motif-containing protein 66

Gene Name
Tripartite motif-containing protein 66
Protein ID
O15016
Chromosome ID
11
HPP Status
2
Protein Name
Tripartite motif-containing protein 66
Synonyms

tripartite motif-containing protein 66

tripartite motif containing 66

tripartite motif-containing 66

TIF1DELTA

KIAA0298

transcriptional intermediary factor 1 delta

chromosome 11 open reading frame 29

C11orf29

TIF1D


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=TRIM66 ]
Chromosomal Position
11p15.4 | Start:8612037 End:8612037
Sequence
O15016.fasta
Description

UniProtKB Summary for TRIM66
Function: May function as transcription repressor; The repressive effects are mediated, at least in part, by recruitment of deacetylase activity. May play a role as negative regulator of postmeiotic genes acting through CBX3 complex formation and centromere association (By similarity)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=TRIM66 ]
External IDs
Hgnc ID: 29005 EntrezGene ID: 9866 Ensembl ID: ENSG00000166436
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=TRIM66 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
15322135Data suggest a role for transcriptional intermediary factor 1 (TIF1) delta in heterochromatin-mediated gene silencing during postmeiotic phases of spermatogenesis.2010-01-21
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidenceTRI66_HUMANTRI66_MOUSE1216125183.69102.88160511216112420.00E+001919
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
TRI66_HUMANIPR000315GO:0005622DomainZinc finger, B-boxCellular Componentintracellular
TRI66_HUMANIPR000315GO:0008270DomainZinc finger, B-boxMolecular Functionzinc ion binding
TRI66_HUMANIPR001487GO:0005515DomainBromodomainMolecular Functionprotein binding
TRI66_HUMANIPR001965GO:0005515DomainZinc finger, PHD-typeMolecular Functionprotein binding
TRI66_HUMANIPR001965GO:0008270DomainZinc finger, PHD-typeMolecular Functionzinc ion binding
TRI66_HUMANIPR003649GO:0005622DomainB-box, C-terminalCellular Componentintracellular
TRI66_HUMANIPR019787GO:0005515DomainZinc finger, PHD-fingerMolecular Functionprotein binding
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/O15016_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Showing 1-3 of 3 items.

Proteomics DB

Peptide SequenceSearch EngineScoreThreshold ScoreIdentification IDExperiment IDAnnotation
LVLSLCCNNLSLPFHEPVSPLARMaxquant265.108430734182353
LVLSLCCNNLSLPFHEPVSPLARMaxquant227.5908430734192353
PALPLDKMaxquant119.5601317240721-1
Evidence File
/mnt/mpp/ms_data/O15016_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB