NKX2-8:Homeobox protein Nkx-2.8

Gene Name
Homeobox protein Nkx-2.8
Protein ID
O15522
Chromosome ID
14
HPP Status
2
Protein Name
Homeobox protein Nkx-2.8
Synonyms

NKX-2.8

NKX2G

Nkx2-9

NKX2.8

NK2 transcription factor related, locus 8

NKX2H

Homeobox protein NK-2 homolog H

homeobox protein NK-2 homolog H

NK-2 homolog H (Drosophila)

NK2 homeobox 8

NK-2 homolog 8

NK2 transcription factor related, locus 8 (Drosophila)

NK-2 homolog H

homeobox protein Nkx-2.8


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=NKX2-8 ]
Chromosomal Position
14q13.3 | Start:36580579 End:36580579
Sequence
O15522.fasta
Description

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=NKX2-8 ]
External IDs
Hgnc ID: 16364 EntrezGene ID: 26257 Ensembl ID: ENSG00000136327
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=NKX2-8 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
12167706A murine Nkx2.8 was isolated from the Hepal-6 cell line and showed oligonucleotide binding competitive with fetoprotein transcription factor.2010-01-21
19279207Coactivation of the TTF-1 and NKX2-8 pathways identified a cluster of lung cancer patients with poor survival and were shown to exhibit resistance to cisplatin2010-01-21
21148747Most tumors have low expression of Nkx2-8, and its expression can inhibit growth of some lung cancer cells.2011-08-20
22223847overexpression of Nkx2.8 resulted in downregulation of p-FOXO3a and inhibition of MEK/ERK pathway activity. silencing Nkx2.8 led to upregulation of p-FOXO3a and increase of MEK/ERK pathway activity.2012-05-12
23604637Results show that Nkx2-8 functions as a tumor suppressor in esophageal squamous cell carcinoma (ESCC), the downregulation of which contributes to NF-kappaB P65 activation and ESCC angiogenesis.2013-08-31
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidenceNKX28_HUMANNKX22_MOUSE23911361.9547.28332831951272293E-28121
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
NKX28_HUMANIPR001356GO:0003700DomainHomeobox domainMolecular Functionsequence-specific DNA binding transcription factor activity
NKX28_HUMANIPR001356GO:0043565DomainHomeobox domainMolecular Functionsequence-specific DNA binding
NKX28_HUMANIPR009057GO:0003677DomainHomeodomain-likeMolecular FunctionDNA binding
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/O15522_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/O15522_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Showing 1-3 of 3 items.

Proteomics DB

Peptide SequenceSearch EngineScoreThreshold ScoreIdentification IDExperiment IDAnnotation
SLLDLPEQDAQHLPRMaxquant163.9902687210103
EQLASLLRMaxquant119.4101337964342-1
DGQPCGGGGGGEVGTAAAQEKMaxquant118.3702682121093
Evidence File
/mnt/mpp/ms_data/O15522_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB