ADAM20:Disintegrin and metalloproteinase domain-containing protein 20

Gene Name
Disintegrin and metalloproteinase domain-containing protein 20
Protein ID
O43506
Chromosome ID
14
HPP Status
2
Protein Name
Disintegrin and metalloproteinase domain-containing protein 20
Synonyms

ADAM 20

a disintegrin and metalloproteinase domain 20

disintegrin and metalloproteinase domain-containing protein 20

ADAM metallopeptidase domain 20

EC 3.4.24.-


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ADAM20 ]
Chromosomal Position
14q24.2 | Start:70522358 End:70522358
Sequence
O43506.fasta
Description

Entrez Gene Summary for ADAM20
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The expression of this gene is testis-specific. (provided by RefSeq, Jul 2008)

UniProtKB Summary for ADAM20
Function: May be involved in sperm maturation and/or fertilization

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ADAM20 ]
External IDs
Hgnc ID: 199 EntrezGene ID: 8748 Ensembl ID: ENSG00000134007
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ADAM20 ]
Reference Source
http://www.nextprot.org

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
ADA20_HUMANIPR001590GO:0004222DomainPeptidase M12B, ADAM/reprolysinMolecular Functionmetalloendopeptidase activity
ADA20_HUMANIPR001590GO:0006508DomainPeptidase M12B, ADAM/reprolysinBiological Processproteolysis
ADA20_HUMANIPR002870GO:0004222DomainPeptidase M12B, propeptideMolecular Functionmetalloendopeptidase activity
ADA20_HUMANIPR002870GO:0006508DomainPeptidase M12B, propeptideBiological Processproteolysis
ADA20_HUMANIPR002870GO:0008270DomainPeptidase M12B, propeptideMolecular Functionzinc ion binding
ADA20_HUMANIPR006586GO:0004222DomainADAM, cysteine-richMolecular Functionmetalloendopeptidase activity
ADA20_HUMANIPR006586GO:0006508DomainADAM, cysteine-richBiological Processproteolysis
ADA20_HUMANIPR024079GO:0008237DomainMetallopeptidase, catalytic domainMolecular Functionmetallopeptidase activity
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/O43506_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/O43506_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Showing 1-1 of 1 item.

Proteomics DB

Evidence File
/mnt/mpp/ms_data/O43506_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB