PSMB11:Proteasome subunit beta type-11

Gene Name
Proteasome subunit beta type-11
Protein ID
A5LHX3
Chromosome ID
14
HPP Status
2
Protein Name
Proteasome subunit beta type-11
Synonyms

proteasome subunit beta type-11

BETA5T

proteasome subunit beta-5t

Proteasome subunit beta-5t

proteasome subunit beta 5T

proteasome (prosome, macropain) subunit, beta type, 11

EC 3.4.25.1


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=PSMB11 ]
Chromosomal Position
14q11.2 | Start:23042167 End:23042167
Sequence
A5LHX3.fasta
Description

Entrez Gene Summary for PSMB11
Proteasomes generate peptides that are presented by major histocompatibility complex (MHC) I molecules to other cells of the immune system. Proteolysis is conducted by 20S proteasomes, complexes of 28 subunits arranged as a cylinder in 4 heteroheptameric rings: alpha-1 to -7, beta-1 to -7, beta-1 to -7, and alpha-1 to -7. The catalytic subunits are beta-1 (PSMB6; MIM 600307), beta-2 (PSMB7; MIM 604030), and beta-5 (PSMB5; MIM 600306). Three additional subunits, beta-1i (PSMB9; MIM 177045), beta-2i (PSMB10; MIM 176847), and beta-5i (PSMB8; MIM 177046), are induced by gamma-interferon (IFNG; MIM 147570) and are preferentially incorporated into proteasomes to make immunoproteasomes. PSMB11, or beta-5t, is a catalytic subunit expressed exclusively in cortical thymic epithelial cells (Murata et al., 2007 (PubMed 17540904)).(supplied by OMIM, Mar 2008)

UniProtKB Summary for PSMB11
Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome (By similarity). Plays a pivotal role in development of CD8-positive T cells (By similarity)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=PSMB11 ]
External IDs
Hgnc ID: 31963 EntrezGene ID: 122706 Ensembl ID: ENSG00000222028
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=PSMB11 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
17540904results suggest a key role for beta5t in generating the MHC class I-restricted CD8(+) T cell repertoire during thymic selection2010-01-21
19289856Human beta5t was expressed in approximately 80% of cortical thymic epithelial cells and some cortical dendritic cells2010-01-21
21836487Proteasome beta5t is expressed in most type B and in some type AB thymomas and is a marker useful in differentiating type B3 thymomas from thymic carcinomas when used in combination with other diagnostic markers.2011-10-08
21941364provide the first evidence that the mechanism underlying BTZ resistance in these tumor cells is impaired binding of BTZ to the mutant beta5 subunit of the proteasome2012-06-09
24293611Histological diversity of type AB thymoma correlates with expression of a functional marker beta5t and abundance of TdT-positive lymphocytes.2014-04-12
25556590We analysed thymic tissues from patients with trisomy 13 (n = 4), trisomy 18 (n = 14) and trisomy 21 (n = 13) for histological alterations, and for the expression of functionally important molecules such as beta5t, a thymoproteasome subunit, and cathepsins.2016-04-30
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidencePSB11_HUMANPSB11_MOUSE30030282.78100.67501130013025.00E-120426
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
PSB11_HUMANIPR000243GO:0004175FamilyPeptidase T1A, proteasome beta-subunitMolecular Functionendopeptidase activity
PSB11_HUMANIPR000243GO:0005839FamilyPeptidase T1A, proteasome beta-subunitCellular Componentproteasome core complex
PSB11_HUMANIPR000243GO:0051603FamilyPeptidase T1A, proteasome beta-subunitBiological Processproteolysis involved in cellular protein catabolic process
PSB11_HUMANIPR001353GO:0004298FamilyProteasome, subunit alpha/betaMolecular Functionthreonine-type endopeptidase activity
PSB11_HUMANIPR001353GO:0005839FamilyProteasome, subunit alpha/betaCellular Componentproteasome core complex
PSB11_HUMANIPR001353GO:0051603FamilyProteasome, subunit alpha/betaBiological Processproteolysis involved in cellular protein catabolic process
PSB11_HUMANIPR016050GO:0004175Conserved_siteProteasome, beta-type subunit, conserved siteMolecular Functionendopeptidase activity
PSB11_HUMANIPR016050GO:0005839Conserved_siteProteasome, beta-type subunit, conserved siteCellular Componentproteasome core complex
PSB11_HUMANIPR016050GO:0051603Conserved_siteProteasome, beta-type subunit, conserved siteBiological Processproteolysis involved in cellular protein catabolic process
PSB11_HUMANIPR023333GO:0004298FamilyProteasome B-type subunitMolecular Functionthreonine-type endopeptidase activity
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

KEGG Pathways

Pathway IDDatabase NamePathway Name
hsa03050KEGG PATHWAYProteasome
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




Showing 1-6 of 6 items.

gpmDB

Peptide SequenceEvidence LevelLog ENumber Of ObservationSpectraAccession IDProteotypicityAnnotation
LAHGTTTLAFRyellow-7.1381ENSP00000386212Proteotypic
LAHGTTTLAFRyellow-7.1381ENSP00000386212Proteotypic
LAHGTTTLAFRyellow-7.1381ENSP00000386212Proteotypic
LAHGTTTLAFRyellow-7.1381ENSP00000386212Proteotypic
LAHGTTTLAFRyellow-6.1381ENSP00000386212Proteotypic
LAHGTTTLAFRyellow-6.1381ENSP00000386212Proteotypic
Evidence File
/mnt/mpp/ms_data/A5LHX3_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


Showing 1-4 of 4 items.

PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
DAYSGGSVDLFHVR0.0055020205017712,Mascot:expectation;24.38,Mascot:score;PXD000039_27341_35789_A5LHX3_DAYSGGSVDLFHVRPXD000039;PRIDE_Exp_Complete_Ac_27341.xml;spectrum=35789
DAYSGGSVDLFHVR0.0055020205017712,Mascot:expectation;24.38,Mascot:score;PXD000039_27341_35789_A5LHX3_DAYSGGSVDLFHVRPXD000039;PRIDE_Exp_Complete_Ac_27341.xml;spectrum=35789
DAYSGGSVDLFHVR0.0055020205017712,Mascot:expectation;24.38,Mascot:score;PXD000039_27341_35789_A5LHX3_DAYSGGSVDLFHVRPXD000039;PRIDE_Exp_Complete_Ac_27341.xml;spectrum=35789
DAYSGGSVDLFHVR0.0055020205017712,Mascot:expectation;24.38,Mascot:score;PXD000039_27341_35789_A5LHX3_DAYSGGSVDLFHVRPXD000039;PRIDE_Exp_Complete_Ac_27341.xml;spectrum=35789
Evidence File
/mnt/mpp/ms_data/A5LHX3_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Showing 1-1 of 1 item.

Proteomics DB

Evidence File
/mnt/mpp/ms_data/A5LHX3_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB