CLLU1:Chronic lymphocytic leukemia up-regulated protein 1

Gene Name
Chronic lymphocytic leukemia up-regulated protein 1
Protein ID
Chromosome ID
HPP Status
Protein Name
Chronic lymphocytic leukemia up-regulated protein 1

chronic lymphocytic leukemia up-regulated 1

chronic lymphocytic leukemia up-regulated protein 1

[Reference: ]
Chromosomal Position
12q22 | Start:92421531 End:92421531

[Reference: ]
External IDs
Hgnc ID: 29841 EntrezGene ID: 574028 Ensembl ID: ENSG00000257127
[Reference: ]
Reference Source

Gene Reference Into Function (GeneRIF)

PubMed IDGeneRIF TextLast Update
16339396CLLU1 is the first disease-specific gene identified in chronic lymphocytic leukemia.2010-01-21
17284524CLLU1 has a role in progression of chronic lymphocytic leukemia2010-01-21
17786715The expression levels of CLLU1 were significantly increased in B + C CLL patients at Binet stage compared with those at Binet stage A (P = 0.005).2010-01-21
18457263CLLU1 expression was significantly associated with clinical stage and CD38 expression in chronic lymphocytic leukemia.2010-01-21
19212335The CLLU1 expression level is a stable and inherent feature of the chronic lymphocytic leukemia clone2010-01-21
19726446CLLU1 is a novel human-specific protein-coding gene.2009-09-10
21323738Assessment of blood CLLU1 levels can be used as a reliable marker of tumor burden and has the potential to complement currently used techniques for minimal residual disease monitoring in patients with chronic lymphocytic leukemia.2011-06-25
22738889Analysis of CLLU1 expression is a rapid and reliable tool that may facilitate the diagnosis of mature B-cell neoplasms especially in inconclusive cases.2012-10-13
22899580the level of CLLU1 mRNA expression provided prognostic information in patients with CLL.2013-11-30


Relevant citations within the PubMed literature


Putative/known Functions


Homologues, Orthologues, Paralogues and Family

Sequence Similarity and Functional Annotation

Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
All Reviewed HumanCLLU1_HUMANCLLU1_HUMAN12112110010000112111215.00E-66245
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications

Protein Protein Interactions

Best Available Mass Spectra without FDR


Evidence File
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803. ">Global Proteome Machine Database - THE GPM


Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456. ">PRIDE Archive

Proteomics DB

Evidence File
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7. ">Proteomics DB