NPFF:Pro-FMRFamide-related neuropeptide FF

Gene Name
Pro-FMRFamide-related neuropeptide FF
Protein ID
O15130
Chromosome ID
12
HPP Status
3
Protein Name
Pro-FMRFamide-related neuropeptide FF
Synonyms

FMRFamide-related peptides

FMRFAL

pro-FMRFamide-related neuropeptide FF

neuropeptide FF-amide peptide precursor


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=NPFF ]
Chromosomal Position
12q13.13 | Start:53506690 End:53506690
Sequence
O15130.fasta
Description

Entrez Gene Summary for NPFF
FMFRamide-related protein precursor plays a role in the regulation of heart rate and blood pressure and the modulation of morphine-induced antinociception. FMRFAL encodes a preproprotein which is cleaved to form two active peptides with similar function. (provided by RefSeq, Jul 2008)

UniProtKB Summary for NPFF
Function: Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=NPFF ]
External IDs
Hgnc ID: 7901 EntrezGene ID: 8620 Ensembl ID: ENSG00000139574
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=NPFF ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
16336216expression of hNPFF2 receptor mRNA was up-regulated by neuropeptide FF2010-01-21
17224450neuropeptide FF and micro-opioid receptor association could be a possible molecular basis for anti-opioid activity2010-01-21
17854890the findings from the early studies on the analgesic and morphine modulating activities suggested a role for NPFF in pain modulation--review2010-01-21
21120930reduction of NPFF release within the dorsal motor nucleus and ambiguus nucleus could serve as a possible cause of the impairment of cardiac vagal control in hypertensive patients2011-03-19
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalianNPFF_HUMANNPFF_BOVIN1139972.7387.6126116113171152E-31130
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
NPFF_HUMANIPR008065GO:0005184FamilyFMRFamide-related peptideMolecular Functionneuropeptide hormone activity
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




Proteomics DB

Evidence File
/mnt/mpp/ms_data/O15130_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB