CLEC6A:C-type lectin domain family 6 member A

Gene Name
C-type lectin domain family 6 member A
Protein ID
Q6EIG7
Chromosome ID
12
HPP Status
2
Protein Name
C-type lectin domain family 6 member A
Synonyms

CLEC4N

Dectin-2

dendritic cell-associated C-type lectin 2

Dendritic cell-associated C-type lectin 2

CLECSF10

C-type lectin domain family 6, member A

C-type lectin superfamily member 10

DECTIN2

dectin-2

C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 10

DC-associated C-type lectin 2

dectin 2

C-type lectin domain family 6 member A


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=CLEC6A ]
Chromosomal Position
12p13.31 | Start:8455926 End:8455926
Sequence
Q6EIG7.fasta
Description

Entrez Gene Summary for CLEC6A
Like dectin-1 (CLEC7A; MIM 606264), CLEC6A, or dectin-2, is a type II membrane receptor with an extracellular C-type lectin-like domain fold. However, unlike dectin-1, dectin-2 lacks an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain (Kanazawa et al., 2004 (PubMed 15175046)).(supplied by OMIM, Nov 2010)

UniProtKB Summary for CLEC6A
Function: Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway (By similarity)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=CLEC6A ]
External IDs
Hgnc ID: 14556 EntrezGene ID: 93978 Ensembl ID: ENSG00000205846
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=CLEC6A ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
15810886human DECTIN-2 has a role in innate immunity2010-01-21
21283787Thus, dectin-1 and dectin-2 control adaptive T(H)-17 immunity to fungi via Malt1-dependent activation of c-Rel.2011-05-07
23606632The Dectin-2 possess a single extracellular conserved C-type lectin-like domain and are capable of mediating intracellular signalling either directly, through integral signalling domains, or indirectly, by associating with signalling adaptor molecules.2014-10-25
24129160our data show a requirement for Dectin-2 in alveolar macrophage induction of cysteinyl leukotrienes and in the initiation of airway inflammation.2014-12-20
25659141human plasmacytoid dendritic cells directly recognize A. fumigatus hyphae via Dectin-22016-01-23
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidenceCLC6A_HUMANCLC6A_MOUSE20921168.25100.96632120912097.00E-81295
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
CLC6A_HUMANIPR001304GO:0030246DomainC-type lectinMolecular Functioncarbohydrate binding
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/Q6EIG7_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


Proteomics DB

Evidence File
/mnt/mpp/ms_data/Q6EIG7_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB