ACSM4:Acyl-coenzyme A synthetase ACSM4, mitochondrial

Gene Name
Acyl-coenzyme A synthetase ACSM4, mitochondrial
Protein ID
P0C7M7
Chromosome ID
12
HPP Status
2
Protein Name
Acyl-coenzyme A synthetase ACSM4, mitochondrial
Synonyms

acyl-CoA synthetase medium-chain family member 4

acyl-coenzyme A synthetase ACSM4, mitochondrial

Acyl-CoA synthetase medium-chain family member 4

"similar to olfactory specific medium-chain acyl CoA synthetase"

EC 6.2.1.2


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ACSM4 ]
Chromosomal Position
12p13.31 | Start:7304284 End:7304284
Sequence
P0C7M7.fasta
Description

UniProtKB Summary for ACSM4
Function: Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro) (By similarity)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ACSM4 ]
External IDs
Hgnc ID: 32016 EntrezGene ID: 341392 Ensembl ID: ENSG00000215009
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ACSM4 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
20877624Observational study of gene-disease association. (HuGE Navigator)2010-12-05
23982661SNPs associated with rapid AIDS progression2014-03-22
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidenceACSM4_HUMANACSM3_MOUSE58057859.6999.662312157715770.00E+00734
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
ACSM4_HUMANIPR000873GO:0003824DomainAMP-dependent synthetase/ligaseMolecular Functioncatalytic activity
ACSM4_HUMANIPR000873GO:0008152DomainAMP-dependent synthetase/ligaseBiological Processmetabolic process
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

KEGG Pathways

Pathway IDDatabase NamePathway Name
hsa00650KEGG PATHWAYButanoate metabolism
hsa01100KEGG PATHWAYMetabolic pathways
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/P0C7M7_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


Showing 1-2 of 2 items.

PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
AFVVLAAPFK27.31,Mascot:score;0.00373758436473578,Mascot:expectation;PXD001327_39774_4460_P0C7M7_AFVVLAAPFKPXD001327;ZR-75-1_cyt1_2.mgf;index=18261
GQEIKPGSMGK0.00848355743319605,Mascot:expectation;25.62,Mascot:score;PXD002990_58250_52131_P0C7M7_GQEIKPGSMGKPXD002990;F150768.mgf;index=152631
Evidence File
/mnt/mpp/ms_data/P0C7M7_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Proteomics DB

Evidence File
/mnt/mpp/ms_data/P0C7M7_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB