ADAMTS20:A disintegrin and metalloproteinase with thrombospondin motifs 20

Gene Name
A disintegrin and metalloproteinase with thrombospondin motifs 20
Protein ID
P59510
Chromosome ID
12
HPP Status
2
Protein Name
A disintegrin and metalloproteinase with thrombospondin motifs 20
Synonyms

ADAMTS-20

a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 20

GON-1

ADAM-TS 20

ADAM-TS20

A disintegrin and metalloproteinase with thrombospondin motifs 20

ADAM metallopeptidase with thrombospondin type 1 motif, 20

EC 3.4.24.-


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ADAMTS20 ]
Chromosomal Position
12q12 | Start:43353866 End:43353866
Sequence
P59510.fasta
Description

Entrez Gene Summary for ADAMTS20
The protein encoded by this gene is a member of the ADAMTS family of zinc-dependent proteases. The encoded protein has a signal peptide that is cleaved to release the mature peptide, which is secreted and found in the extracellular matrix. This protein may be involved in tissue remodeling. (provided by RefSeq, Sep 2011)

UniProtKB Summary for ADAMTS20
Function: May play a role in tissue-remodeling process occurring in both normal and pathological conditions. May have a protease-independent function in the transport from the endoplasmic reticulum to the Golgi apparatus of secretory cargos, mediated by the GON domain

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ADAMTS20 ]
External IDs
Hgnc ID: 17178 EntrezGene ID: 80070 Ensembl ID: ENSG00000173157
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ADAMTS20 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
12514189ADAMTS-9 and ADAMTS-20 have an identical modular structure, are distinct in possessing 15 thrombospondin type I repeats and a unique C-terminal domain, and have a similar gene structure2010-01-21
12562771This protein is identified and characterized and its relation to other disintegrins and thrombospondin 1 repeats is examined.2010-01-21
20221248Observational study of gene-disease association. (HuGE Navigator)2010-04-07
25798845In summary, this study provides genetic evidence for a role of ADAMTS20 in CL/P development in dogs and as a candidate gene for CL/P development in humans.2016-01-02
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation



Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/P59510_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/P59510_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Proteomics DB

Evidence File
/mnt/mpp/ms_data/P59510_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB