IFNA16:Interferon alpha-16
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Gene Name
Interferon alpha-16 |
Protein ID
P05015 |
Chromosome ID
9 |
HPP Status
2 |
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Protein Name
Interferon alpha-16 |
Synonyms
interferon alpha-WA IFN-alphaO IFN-alpha-N-protein IFN-alpha-16 Interferon alpha-WA interferon, alpha 16 interferon alpha-16 [Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=IFNA16  ] |
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Chromosomal Position
9p21.3 | Start:21216373 End:21216373 |
Sequence
P05015.fasta |
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Description
UniProtKB Summary for IFNA16Function: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase [Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=IFNA16 ] |
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External IDs
Hgnc ID: 5421 EntrezGene ID: 3449 Ensembl ID: ENSG00000147885 [Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=IFNA16 ] |
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Reference Source
http://www.nextprot.org |
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Gene Reference Into Function (GeneRIF)
| PubMed ID | GeneRIF Text | Last Update |
|---|---|---|
| 20574843 | Observational study of gene-disease association. (HuGE Navigator) | 2010-09-15 |
| 20588308 | Observational study of gene-disease association. (HuGE Navigator) | 2010-09-15 |
| Reference http://www.ncbi.nlm.nih.gov/gene/about-generif ftp://ftp.ncbi.nih.gov/gene/GeneRIF/ | ||
OMICSDI Browser
Relevant citations within the PubMed literature
Putative/known Functions
Localisation
Homologues, Orthologues, Paralogues and Family
Sequence Similarity and Functional Annotation
Sequence Similarity
| Db Name | Query Uni | Subject Uni | Sequence Length | Alignment Length | Identity | Coverage | Mismatches | Gap Openings | Query Start | Query End | Subject Start | Subject End | Evalue | Bit Score |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Reviewed non-human mammalian with experimental evidence | IFN16_HUMAN | IFNA5_MOUSE | 189 | 189 | 60.85 | 100 | 74 | 0 | 1 | 189 | 1 | 189 | 4E-64 | 239 |
| Reference Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83. | ||||||||||||||
InterProScan Annotation
| Uniprot ID | Interpro ID | Go ID | Type | Name | Category | Description |
|---|---|---|---|---|---|---|
| IFN16_HUMAN | IPR000471 | GO:0005126 | Family | Interferon alpha/beta/delta | Molecular Function | cytokine receptor binding |
| IFN16_HUMAN | IPR000471 | GO:0005576 | Family | Interferon alpha/beta/delta | Cellular Component | extracellular region |
| IFN16_HUMAN | IPR000471 | GO:0006952 | Family | Interferon alpha/beta/delta | Biological Process | defense response |
| Reference Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83. | ||||||
KEGG Pathways
| Pathway ID | Database Name | Pathway Name |
|---|---|---|
| hsa04060 | KEGG PATHWAY | Cytokine-cytokine receptor interaction |
| hsa04140 | KEGG PATHWAY | Regulation of autophagy |
| hsa04620 | KEGG PATHWAY | Toll-like receptor signaling pathway |
| hsa04622 | KEGG PATHWAY | RIG-I-like receptor signaling pathway |
| hsa04623 | KEGG PATHWAY | Cytosolic DNA-sensing pathway |
| hsa04630 | KEGG PATHWAY | Jak-STAT signaling pathway |
| hsa04650 | KEGG PATHWAY | Natural killer cell mediated cytotoxicity |
| hsa05152 | KEGG PATHWAY | Tuberculosis |
| hsa05160 | KEGG PATHWAY | Hepatitis C |
| hsa05162 | KEGG PATHWAY | Measles |
| hsa05164 | KEGG PATHWAY | Influenza A |
| hsa05168 | KEGG PATHWAY | Herpes simplex infection |
| hsa05320 | KEGG PATHWAY | Autoimmune thyroid disease |
| Reference Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83. | ||