AQP6:Aquaporin-6

Gene Name
Aquaporin-6
Protein ID
Q13520
Chromosome ID
12
HPP Status
2
Protein Name
Aquaporin-6
Synonyms

Kidney-specific aquaporin

hKID

KID

AQP-6

kidney-specific aquaporin

Aquaporin-2-like

aquaporin-6, kidney specific

AQP2L

aquaporin 2-like, kidney specific

aquaporin 6, kidney specific

aquaporin-6


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=AQP6 ]
Chromosomal Position
12q13.12 | Start:49967194 End:49967194
Sequence
Q13520.fasta
Description

Entrez Gene Summary for AQP6
The protein encoded by this gene is an aquaporin protein, which functions as a water channel in cells. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This protein is specific for the kidney. This gene and related family members AQP0, AQP2, and AQP5 reside in a cluster on chromosome 12q13. (provided by RefSeq, Jul 2008)

UniProtKB Summary for AQP6
Function: Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism (By similarity)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=AQP6 ]
External IDs
Hgnc ID: 639 EntrezGene ID: 363 Ensembl ID: ENSG00000086159
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=AQP6 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
12177001the primary role of AQP6 may be in cellular regulation2010-01-21
19680475Data have identified AQP6 s valuable markers for renal oncocytomas.2010-01-21
20461409Expression of AQP1, AQP4, or AQP6 mRNA did not differ in vestibular endorgans from patients with Meniere's disease.2010-09-06
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidenceAQP6_HUMANAQP6_RAT28227776.1798.23641428012752.00E-107384
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
AQP6_HUMANIPR000425GO:0005215FamilyMajor intrinsic proteinMolecular Functiontransporter activity
AQP6_HUMANIPR000425GO:0006810FamilyMajor intrinsic proteinBiological Processtransport
AQP6_HUMANIPR000425GO:0016020FamilyMajor intrinsic proteinCellular Componentmembrane
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/Q13520_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/Q13520_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Proteomics DB

Evidence File
/mnt/mpp/ms_data/Q13520_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB