FUT5:Alpha-(1,3)-fucosyltransferase 5

Gene Name
Alpha-(1,3)-fucosyltransferase 5
Protein ID
Q11128
Chromosome ID
19
HPP Status
2
Protein Name
Alpha-(1,3)-fucosyltransferase 5
Synonyms

Galactoside 3-L-fucosyltransferase

galactoside 3-L-fucosyltransferase

Fuc-TV

fucosyltransferase V

FucT-V

fucT-V

alpha-(1,3)-fucosyltransferase 5

FUC-TV

Fucosyltransferase V

fucosyltransferase 5 (alpha (1,3) fucosyltransferase)

alpha (1,3) fucosyltransferase

Fucosyltransferase 5

EC 2.4.1.65


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=FUT5 ]
Chromosomal Position
19p13.3 | Start:5865826 End:5865826
Sequence
Q11128.fasta
Description

UniProtKB Summary for FUT5
Function: May catalyze alpha-1,3 glycosidic linkages involved in the expression of VIM-2, Lewis X/SSEA-1 and sialyl Lewis X antigens

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=FUT5 ]
External IDs
Hgnc ID: 4016 EntrezGene ID: 2527 Ensembl ID: ENSG00000130383
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=FUT5 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
14601054Prostatic cancer cell transfected with this enzyme adhered to prostatic stromal cells in vitro with higher affinity than mock-transfected cancer cells.2010-01-21
17148576FUT5 is a receptor of glycodelin-A and zona pellucida proteins, and glycodelin-A inhibits spermatozoa-zona binding by blocking the binding of sperm FUT5 to the zona pellucida2010-01-21
19349624results suggested that PKR is the primary target for HSV-1 early RNA during induction of FUT3, FUT5, and FUT62010-01-21
20677162Observational study of genotype prevalence. (HuGE Navigator)2010-09-15
21978830down-regulation of FUT3 and FUT5 reduces the expression of sialyl-Lewis antigens and the adhesion capacities of gastric cancer cells and allows to identify the specific alpha1-3,4 fucosyltransferases implicated in the Lewis antigens synthesis2012-01-28
22619806FUT5 was expressed on spermatid membranes and in serum, but not in seminal plasma, vaginal fluid and saliva. Expression was localized on head of spermatids.2012-12-22
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalianFUT5_HUMANFUT5_PANTR37437498.1310070137413740.00E+00762
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

KEGG Pathways

Pathway IDDatabase NamePathway Name
hsa00601KEGG PATHWAYGlycosphingolipid biosynthesis - lacto and neolacto series
hsa01100KEGG PATHWAYMetabolic pathways
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/Q11128_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


MaxQB

Evidence File
/mnt/mpp/ms_data/Q11128_maxqb.txt
Reference
Christoph Schaab, Tamar Geiger, Gabriele Stoehr, Juergen Cox and Matthias Mann: "Analysis of high-accuracy, quantitative proteomics data in the MaxQB database", Mol Cell Proteomics 11 (2012) M111.014068.
http://maxqb.biochem.mpg.de/mxdb/ ">MaxQB


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/Q11128_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Proteomics DB

Evidence File
/mnt/mpp/ms_data/Q11128_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB