PRRX2:Paired mesoderm homeobox protein 2

Gene Name
Paired mesoderm homeobox protein 2
Protein ID
Q99811
Chromosome ID
9
HPP Status
2
Protein Name
Paired mesoderm homeobox protein 2
Synonyms

PMX2

Paired-related homeobox protein 2

paired related homeobox 2

PRX-2

paired-like homeodomain protein PRX2

PRX2

paired-related homeobox protein 2

paired mesoderm homeobox protein 2


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=PRRX2 ]
Chromosomal Position
9q34.11 | Start:129665641 End:129665641
Sequence
Q99811.fasta
Description

Entrez Gene Summary for PRRX2
The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation. (provided by RefSeq, Jul 2008)

UniProtKB Summary for PRRX2
Function: May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=PRRX2 ]
External IDs
Hgnc ID: 21338 EntrezGene ID: 51450 Ensembl ID: ENSG00000167157
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=PRRX2 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
11893718Encodes homeobox transcription factors that are expressed during vasculogenesis.2010-01-21
17964282Valsartan, a selective Ang II type 1 (AT1) receptor blocker, and N-acetylcysteine, an antioxidant, inhibited both of these modifications, indicating the contribution of AT1 receptor and reactive oxygen species to oxidation of Prx2.2010-01-21
20634891Observational study of gene-disease association. (HuGE Navigator)2010-09-15
21385867Model for the exceptional reactivity of peroxiredoxins 2 and 3 with hydrogen peroxide: a kinetic and computational study.2011-07-30
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation



Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




Showing 1-20 of 30 items.

gpmDB

Peptide SequenceEvidence LevelLog ENumber Of ObservationSpectraAccession IDProteotypicityAnnotation
SYSQEAAIEQPVAPRgreen-14.5131ENSP00000361547Proteotypic
SYSQEAAIEQPVAPRgreen-14.5131ENSP00000361547Proteotypic
KNFSVSHLLDLEEVAAAGRgreen-13.6161ENSP00000361547Proteotypic
KNFSVSHLLDLEEVAAAGRgreen-13.6161ENSP00000361547Proteotypic
KNFSVSHLLDLEEVAAAGRgreen-12.5161ENSP00000361547Proteotypic
KNFSVSHLLDLEEVAAAGRgreen-12.5161ENSP00000361547Proteotypic
KNFSVSHLLDLEEVAAAGRgreen-11.4161ENSP00000361547Proteotypic
KNFSVSHLLDLEEVAAAGRgreen-11.4161ENSP00000361547Proteotypic
SYSQEAAIEQPVAPRgreen-11.2131ENSP00000361547Proteotypic
SYSQEAAIEQPVAPRgreen-11.2131ENSP00000361547Proteotypic
KNFSVSHLLDLEEVAAAGRgreen-8.4161ENSP00000361547Proteotypic
KNFSVSHLLDLEEVAAAGRgreen-8.4161ENSP00000361547Proteotypic
SYSQEAAIEQPVAPRgreen-7.9131ENSP00000361547Proteotypic
SYSQEAAIEQPVAPRgreen-7.9131ENSP00000361547Proteotypic
KNFSVSHLLDLEEVAAAGRgreen-7.7161ENSP00000361547Proteotypic
KNFSVSHLLDLEEVAAAGRgreen-7.7161ENSP00000361547Proteotypic
KNFSVSHLLDLEEVAAAGRgreen-7.6161ENSP00000361547Proteotypic
KNFSVSHLLDLEEVAAAGRgreen-7.6161ENSP00000361547Proteotypic
SYSQEAAIEQPVAPRgreen-7.2131ENSP00000361547Proteotypic
SYSQEAAIEQPVAPRgreen-7.2131ENSP00000361547Proteotypic
Evidence File
/mnt/mpp/ms_data/Q99811_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/Q99811_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Showing 1-3 of 3 items.

Proteomics DB

Peptide SequenceSearch EngineScoreThreshold ScoreIdentification IDExperiment IDAnnotation
NFSVSHLLDLEEVAAAGRMaxquant428.10559609976250
NFSVSHLLDLEEVAAAGRMaxquant175.3301285955413-1
RVNLSEARMaxquant148.1401295201807-1
Evidence File
/mnt/mpp/ms_data/Q99811_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB