DMRT2:Doublesex- and mab-3-related transcription factor 2

Gene Name
Doublesex- and mab-3-related transcription factor 2
Protein ID
Q9Y5R5
Chromosome ID
9
HPP Status
2
Protein Name
Doublesex- and mab-3-related transcription factor 2
Synonyms

DSXL-2

Doublesex-like 2 protein

doublesex-like 2 protein

doublesex- and mab-3-related transcription factor 2

"terra-like protein"

DSXL2

doublesex and mab-3 related transcription factor 2

terra-like protein


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=DMRT2 ]
Chromosomal Position
9p24.3 | Start:1050354 End:1050354
Sequence
Q9Y5R5.fasta
Description

Entrez Gene Summary for DMRT2
The protein encoded by this gene belongs to the DMRT gene family, sharing a DM DNA-binding domain with Drosophila 'doublesex' (dsx) and C. elegans mab3, genes involved in sex determination in these organisms. Also, this gene is located in a region of the human genome (chromosome 9p24.3) associated with gonadal dysgenesis and XY sex reversal. Hence this gene is one of the candidates for sex-determining gene(s) on chr 9. (provided by RefSeq, Apr 2010)

UniProtKB Summary for DMRT2
Function: Transcriptional activator that directly regulates early activation of the myogenic determination gene MYF5 by binding in a sequence-specific manner to the early epaxial enhancer element of it. Involved in somitogenesis during embryogenesis and somite development and differentiation into sclerotome and dermomyotome. Required for the initiation and/or maintenance of proper organization of the sclerotome, dermomyotome and myotome (By similarity)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=DMRT2 ]
External IDs
Hgnc ID: 2935 EntrezGene ID: 10655 Ensembl ID: ENSG00000173253
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=DMRT2 ]
Reference Source
http://www.nextprot.org

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidenceDMRT2_HUMANDMRT2_MOUSE56145989.9881.824601035611035610856
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
DMRT2_HUMANIPR001275GO:0043565DomainDM DNA-binding domainMolecular Functionsequence-specific DNA binding
DMRT2_HUMANIPR026607GO:0003700FamilyDMRT/protein doublesex/protein male abnormal 3Molecular Functionsequence-specific DNA binding transcription factor activity
DMRT2_HUMANIPR026607GO:0005634FamilyDMRT/protein doublesex/protein male abnormal 3Cellular Componentnucleus
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/Q9Y5R5_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/Q9Y5R5_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Proteomics DB

Evidence File
/mnt/mpp/ms_data/Q9Y5R5_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB