DMRT2:Doublesex- and mab-3-related transcription factor 2
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Gene Name
Doublesex- and mab-3-related transcription factor 2 |
Protein ID
Q9Y5R5 |
Chromosome ID
9 |
HPP Status
2 |
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Protein Name
Doublesex- and mab-3-related transcription factor 2 |
Synonyms
DSXL-2 Doublesex-like 2 protein doublesex-like 2 protein doublesex- and mab-3-related transcription factor 2 "terra-like protein" DSXL2 doublesex and mab-3 related transcription factor 2 terra-like protein [Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=DMRT2  ] |
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Chromosomal Position
9p24.3 | Start:1050354 End:1050354 |
Sequence
Q9Y5R5.fasta |
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Description
Entrez Gene Summary for DMRT2The protein encoded by this gene belongs to the DMRT gene family, sharing a DM DNA-binding domain with Drosophila 'doublesex' (dsx) and C. elegans mab3, genes involved in sex determination in these organisms. Also, this gene is located in a region of the human genome (chromosome 9p24.3) associated with gonadal dysgenesis and XY sex reversal. Hence this gene is one of the candidates for sex-determining gene(s) on chr 9. (provided by RefSeq, Apr 2010) UniProtKB Summary for DMRT2Function: Transcriptional activator that directly regulates early activation of the myogenic determination gene MYF5 by binding in a sequence-specific manner to the early epaxial enhancer element of it. Involved in somitogenesis during embryogenesis and somite development and differentiation into sclerotome and dermomyotome. Required for the initiation and/or maintenance of proper organization of the sclerotome, dermomyotome and myotome (By similarity) [Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=DMRT2 ] |
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External IDs
Hgnc ID: 2935 EntrezGene ID: 10655 Ensembl ID: ENSG00000173253 [Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=DMRT2 ] |
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Reference Source
http://www.nextprot.org |
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OMICSDI Browser
Relevant citations within the PubMed literature
Putative/known Functions
Localisation
Homologues, Orthologues, Paralogues and Family
Sequence Similarity and Functional Annotation
Sequence Similarity
| Db Name | Query Uni | Subject Uni | Sequence Length | Alignment Length | Identity | Coverage | Mismatches | Gap Openings | Query Start | Query End | Subject Start | Subject End | Evalue | Bit Score |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Reviewed non-human mammalian with experimental evidence | DMRT2_HUMAN | DMRT2_MOUSE | 561 | 459 | 89.98 | 81.82 | 46 | 0 | 103 | 561 | 103 | 561 | 0 | 856 |
| Reference Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83. | ||||||||||||||
InterProScan Annotation
| Uniprot ID | Interpro ID | Go ID | Type | Name | Category | Description |
|---|---|---|---|---|---|---|
| DMRT2_HUMAN | IPR001275 | GO:0043565 | Domain | DM DNA-binding domain | Molecular Function | sequence-specific DNA binding |
| DMRT2_HUMAN | IPR026607 | GO:0003700 | Family | DMRT/protein doublesex/protein male abnormal 3 | Molecular Function | sequence-specific DNA binding transcription factor activity |
| DMRT2_HUMAN | IPR026607 | GO:0005634 | Family | DMRT/protein doublesex/protein male abnormal 3 | Cellular Component | nucleus |
| Reference Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83. | ||||||