LILRA1:Leukocyte immunoglobulin-like receptor subfamily A member 1

Gene Name
Leukocyte immunoglobulin-like receptor subfamily A member 1
Protein ID
O75019
Chromosome ID
19
HPP Status
2
Protein Name
Leukocyte immunoglobulin-like receptor subfamily A member 1
Synonyms

leukocyte immunoglobulin-like receptor subfamily A member 1

leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1

LIR6

Leukocyte immunoglobulin-like receptor 6

LIR-6

leukocyte immunoglobulin-like receptor 6

CD85 antigen-like family member I

CD85i antigen

CD85I


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=LILRA1 ]
Chromosomal Position
19q13.42 | Start:54573879 End:54573879
Sequence
O75019.fasta
Description

Entrez Gene Summary for LILRA1
This gene encodes an activating member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein is predominantly expressed in B cells, interacts with major histocompatibility complex class I ligands, and contributes to the regulation of immune responses. Alternative splicing results in multiple transcript variants encoding different isoforms. (provided by RefSeq, May 2013)

UniProtKB Summary for LILRA1
Function: May act as receptor for class I MHC antigens

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=LILRA1 ]
External IDs
Hgnc ID: 6602 EntrezGene ID: 11024 Ensembl ID: ENSG00000104974
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=LILRA1 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
20237496Observational study of gene-disease association. (HuGE Navigator)2010-04-07
20331378Observational study of gene-disease association. (HuGE Navigator)2010-04-07
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidenceLIRA1_HUMANLIRB3_MOUSE48941053.4183.841863234292206271E-106382
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

KEGG Pathways

Pathway IDDatabase NamePathway Name
hsa04380KEGG PATHWAYOsteoclast differentiation
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/O75019_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


MaxQB

Evidence File
/mnt/mpp/ms_data/O75019_maxqb.txt
Reference
Christoph Schaab, Tamar Geiger, Gabriele Stoehr, Juergen Cox and Matthias Mann: "Analysis of high-accuracy, quantitative proteomics data in the MaxQB database", Mol Cell Proteomics 11 (2012) M111.014068.
http://maxqb.biochem.mpg.de/mxdb/ ">MaxQB


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/O75019_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Proteomics DB

Evidence File
/mnt/mpp/ms_data/O75019_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB