GRIK5:Glutamate receptor ionotropic, kainate 5

Gene Name
Glutamate receptor ionotropic, kainate 5
Protein ID
Chromosome ID
HPP Status
Protein Name
Glutamate receptor ionotropic, kainate 5

glutamate receptor, ionotropic, kainate 5


glutamate receptor KA-2


glutamate receptor KA2

excitatory amino acid receptor 2

glutamate receptor ionotropic, kainate 5


Excitatory amino acid receptor 2

Glutamate receptor KA-2


[Reference: ]
Chromosomal Position
19q13.2 | Start:41998321 End:41998321

Entrez Gene Summary for GRIK5
This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. (provided by RefSeq, Jul 2008)

UniProtKB Summary for GRIK5
Function: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L-glutamate >> AMPA >> NMDA = 1S,3R-ACPD

Tocris Summary for GRIK5
Kainate receptors are members of the ionotropic class of glutamate receptors, which also includes NMDA and AMPA receptors. Kainate receptors have been identified both pre- and post-synaptically. The receptors contribute to excitatory postsynaptic currents in many regions of the CNS and play a role in short- and long-term synaptic plasticity. Kainate receptors consist of GluR5-7 and KA1-2 subunits. Each subunit has an extracellular N-terminus, a cytoplasmic C-terminus, three membrane-spanning segments and a p-loop that dips into the membrane from the cytoplasmic face to form the pore.

[Reference: ]
External IDs
Hgnc ID: 4583 EntrezGene ID: 2901 Ensembl ID: ENSG00000105737
[Reference: ]
Reference Source

Gene Reference Into Function (GeneRIF)

PubMed IDGeneRIF TextLast Update
14511640characterization the trafficking and surface expression of KA22010-01-21
15254951GRIK 5 gene is linked to rapid-onset dystonia-parkinsonism.2010-01-21
16325263Observational study of gene-disease association. (HuGE Navigator)2008-03-13
18247129Functional dysregulation of glutamate uptake was associated with early increases in mRNA and protein expression of the glial glutamate transporter EAAT-2 followed by a sustained decrease in mRNA expression in astrocytes infected with both HHV-6A & HHV-6B.2010-01-21
19086053Observational study of gene-disease association. (HuGE Navigator)2009-01-11
19125103Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)2009-02-11
23288040CaMKII-dependent phosphorylation of GluK5 is responsible for synaptic depression by untrapping of KARs from the PSD and increased diffusion away from synaptic sites.2013-04-20


Relevant citations within the PubMed literature


Putative/known Functions


Homologues, Orthologues, Paralogues and Family

Sequence Similarity and Functional Annotation

Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidenceGRIK5_HUMANGRIK5_RAT98098098.16100171198019790.00E+001816
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

KEGG Pathways

Pathway IDDatabase NamePathway Name
hsa04080KEGG PATHWAYNeuroactive ligand-receptor interaction
hsa04724KEGG PATHWAYGlutamatergic synapse
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications

Protein Protein Interactions

Best Available Mass Spectra without FDR

Showing 1-2 of 2 items.


Peptide SequenceEvidence LevelLog ENumber Of ObservationSpectraAccession IDProteotypicityAnnotation
Evidence File
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803. ">Global Proteome Machine Database - THE GPM


Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456. ">PRIDE Archive

Proteomics DB

Evidence File
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7. ">Proteomics DB