KIR2DS5:Killer cell immunoglobulin-like receptor 2DS5

Gene Name
Killer cell immunoglobulin-like receptor 2DS5
Protein ID
Chromosome ID
HPP Status
Protein Name
Killer cell immunoglobulin-like receptor 2DS5

CD158 antigen-like family member G

natural killer-associated transcript 9


Natural killer-associated transcript 9


CD158g antigen

killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5

killer cell immunoglobulin-like receptor 2DS5

natural killer cell inhibitory receptor


MHC class I NK cell receptor

[Reference: ]
Chromosomal Position
19q13.4 | Start:- End:-

Entrez Gene Summary for KIR2DS5
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. (provided by RefSeq, Jul 2008)

UniProtKB Summary for KIR2DS5
Function: Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells

[Reference: ]
External IDs
Hgnc ID: 6337 EntrezGene ID: 3810
[Reference: ]
Reference Source


Relevant citations within the PubMed literature


Putative/known Functions


Homologues, Orthologues, Paralogues and Family

Sequence Similarity and Functional Annotation

KEGG Pathways

Pathway IDDatabase NamePathway Name
hsa04612KEGG PATHWAYAntigen processing and presentation
hsa04650KEGG PATHWAYNatural killer cell mediated cytotoxicity
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications

Protein Protein Interactions

Best Available Mass Spectra without FDR


Evidence File
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803. ">Global Proteome Machine Database - THE GPM


Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456. ">PRIDE Archive

Proteomics DB

Evidence File
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7. ">Proteomics DB