KIR2DS3:Killer cell immunoglobulin-like receptor 2DS3

Gene Name
Killer cell immunoglobulin-like receptor 2DS3
Protein ID
Q14952
Chromosome ID
19
HPP Status
2
Protein Name
Killer cell immunoglobulin-like receptor 2DS3
Synonyms

natural killer cell inhibitory receptor

NKAT-7

MHC class I NK cell receptor

natural killer-associated transcript 7

NKAT7

killer cell immunoglobulin-like receptor 2DS3

Natural killer-associated transcript 7

killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=KIR2DS3 ]
Chromosomal Position
19q13.42 | Start:54782354 End:54782354
Sequence
Q14952.fasta
Description

Entrez Gene Summary for KIR2DS3
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. (provided by RefSeq, Jul 2008)

UniProtKB Summary for KIR2DS3
Function: Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=KIR2DS3 ]
External IDs
Hgnc ID: 6335 EntrezGene ID: 3808
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=KIR2DS3 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
12559621Positive linkage disequilibrium was seen between KRI2DS2 and KIR2DS3. Positive linkage disequilibrium was seen between KIR3DS1 and KIR2DS3.2010-01-21
15896204Observational study of genotype prevalence. (HuGE Navigator)2008-03-13
16403292Observational study of genotype prevalence. (HuGE Navigator)2008-03-13
16508981Observational study of gene-disease association. (HuGE Navigator)2008-03-13
16829306Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)2008-03-13
17462498KIR2DS3 is a protective factor for chronic graft-versus-host disease.2010-01-21
17498266Observational study of genotype prevalence. (HuGE Navigator)2008-03-13
17868255Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)2008-03-13
17882223Observational study of gene-disease association. (HuGE Navigator)2008-03-13
18074414Observational study of gene-disease association. (HuGE Navigator)2008-03-13
18340360Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)2008-04-03
18480828This focuses on the inheritance of KIR2DS3*001 and *002 to clarify their genetic relationship, and will investigate the diversity of haplotypes containing a KIR2DS3 gene.2010-01-21
18571006Observational study of gene-disease association. (HuGE Navigator)2008-07-02
18643961Observational study of gene-disease association. (HuGE Navigator)2008-09-24
18668235Observational study of genotype prevalence. (HuGE Navigator)2008-08-13
18681957Observational study of gene-disease association. (HuGE Navigator)2008-08-20
18687225Observational study of gene-disease association. (HuGE Navigator)2008-08-20
18764809Genomic and mRNA sequences support the KIR2DS3*002 gene being a hybrid of KIR2DS3*00103 and KIR2DS5.2010-01-21
18778326Observational study of gene-disease association. (HuGE Navigator)2008-09-24
18830515Observational study of genotype prevalence. (HuGE Navigator)2009-01-11
18848853Observational study of genotype prevalence. (HuGE Navigator)2008-11-02
19000141Observational study of genotype prevalence. (HuGE Navigator)2009-03-25
19005473Dramatically reduced surface expression of NK cell receptor KIR2DS3 is attributed to multiple residues throughout the molecule.2010-01-21
19032228Observational study of gene-disease association. (HuGE Navigator)2009-03-25
19046302Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)2009-01-11
19120281Observational study of gene-disease association. (HuGE Navigator)2009-02-11
19169284Observational study of gene-disease association. (HuGE Navigator)2009-02-11
19181658Observational study of gene-disease association. (HuGE Navigator)2009-02-11
19218127Observational study of genotype prevalence. (HuGE Navigator)2009-05-06
19279038Observational study of gene-disease association. (HuGE Navigator)2009-03-25
19309280Observational study of gene-disease association. (HuGE Navigator)2009-04-08
19326408Observational study of gene-disease association. (HuGE Navigator)2009-04-08
19410616Observational study of gene-disease association. (HuGE Navigator)2009-05-17
19421224Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)2009-05-17
19450876Observational study of gene-disease association. (HuGE Navigator)2009-06-24
19489269Observational study of gene-disease association. (HuGE Navigator)2009-06-24
19493232Observational study of gene-disease association. (HuGE Navigator)2009-06-24
19500138KIR2DS3 incompatibilities increased risk of chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation2010-01-21
19527230Observational study of gene-disease association. (HuGE Navigator)2009-06-24
19630074Observational study of gene-disease association. (HuGE Navigator)2009-08-12
19664392Observational study of gene-disease association. (HuGE Navigator)2009-09-16
19683555Observational study of gene-disease association. (HuGE Navigator)2010-04-07
19761533Observational study of gene-disease association. (HuGE Navigator)2009-12-02
19846535Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)2009-12-02
19850842Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)2009-12-02
19861144Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)2009-12-02
19875891Observational study of gene-disease association. (HuGE Navigator)2009-12-02
19897003Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)2009-12-02
19926642Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)2010-01-20
19934297Observational study of gene-disease association. (HuGE Navigator)2010-01-20
19936734Observational study of genotype prevalence. (HuGE Navigator)2010-01-20
19968064Observational study of gene-disease association. (HuGE Navigator)2010-04-07
20082482Observational study of gene-disease association. (HuGE Navigator)2010-04-07
20082646Observational study of genotype prevalence. (HuGE Navigator)2010-04-07
20137308Observational study of gene-disease association. (HuGE Navigator)2010-06-30
20173784Observational study of gene-disease association. (HuGE Navigator)2010-04-07
20173792Observational study of gene-disease association. (HuGE Navigator)2010-04-07
20193031Observational study of genotype prevalence. (HuGE Navigator)2010-04-07
20200544Observational study of genotype prevalence. (HuGE Navigator)2010-04-07
20207982Observational study of gene-disease association. (HuGE Navigator)2010-04-07
20210918Observational study of genotype prevalence. (HuGE Navigator)2010-04-07
20210919Observational study of gene-disease association. (HuGE Navigator)2010-04-07
20331834Observational study of genotype prevalence. (HuGE Navigator)2010-04-07
20356536Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)2010-06-30
20371502Observational study of gene-disease association. (HuGE Navigator)2010-06-30
20371915KIR2DS3 is associated with protection against acute myeloid leukemia.2010-08-02
20426625Observational study of gene-disease association. (HuGE Navigator)2010-06-30
20483367Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)2010-06-30
20492596Observational study of gene-disease association. (HuGE Navigator)2010-06-30
20519398Observational study of gene-disease association. (HuGE Navigator)2010-06-30
20528243Observational study of gene-disease association. (HuGE Navigator)2010-09-15
20580654Observational study of gene-disease association. (HuGE Navigator)2010-09-15
20600442Observational study of gene-disease association. (HuGE Navigator)2010-09-15
20643584Observational study of gene-disease association. (HuGE Navigator)2010-09-15
20650299Observational study of genotype prevalence. (HuGE Navigator)2010-09-15
20652381Observational study of gene-disease association. (HuGE Navigator)2010-09-15
20670355Observational study of genotype prevalence. (HuGE Navigator)2010-09-15
20878400Observational study of gene-disease association. (HuGE Navigator)2010-12-05
20878400Study showed that the activating KIR2DS1 and KIR2DS3 genes associate with fatal outcome in Ebola virus infection.2010-11-27
21402922The Natural Killer cell gene KIR2DS3 was significantly increased in patients with chronic hepatitis C virus infection.2011-07-02
22219647KIR2DS3 and HLA-class I alleles (-Cw*14 and -Cw*17) may play a role in the pathogenesis of the Vogt-Koyanagi-Harada disease.2012-04-28
22653583Data found that the frequencies of KIR2DS1, 2DS3 and 3DS1 were significantly higher in pulmonary tuberculosis patients than in the control group.2012-09-29
23826153the presence of host genetic risk factors, IL28B-T and KIR2DS3 alleles, resulted in increased odds of treatment failure in these rapid virological response negative patients.2014-02-08
24929143The genes KIR2DL5, KIR2DS3 and KIR2DS5 were present in a significantly higher proportion of individuals in the asymptomatic control group than in the malaria cases.2015-04-04
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


KEGG Pathways

Pathway IDDatabase NamePathway Name
hsa04612KEGG PATHWAYAntigen processing and presentation
hsa04650KEGG PATHWAYNatural killer cell mediated cytotoxicity
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/Q14952_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


Showing 1-1 of 1 item.

PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
EGTFNDTLRLIGEHIDGVSKANFSIGR13.36,Spectrum Mill peptide score;PRD000668_22192_1982_Q14952_EGTFNDTLRLIGEHIDGVSKANFSIGRPRD000668;PRIDE_Exp_Complete_Ac_22192.xml;spectrum=1982
Evidence File
/mnt/mpp/ms_data/Q14952_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Proteomics DB

Evidence File
/mnt/mpp/ms_data/Q14952_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB