ZSCAN4:Zinc finger and SCAN domain-containing protein 4

Gene Name
Zinc finger and SCAN domain-containing protein 4
Protein ID
Q8NAM6
Chromosome ID
19
HPP Status
2
Protein Name
Zinc finger and SCAN domain-containing protein 4
Synonyms

ZNF494

zinc finger protein 494

Zinc finger protein 494

zinc finger and SCAN domain-containing protein 4

zinc finger and SCAN domain containing 4


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ZSCAN4 ]
Chromosomal Position
19q13.43 | Start:57668935 End:57668935
Sequence
Q8NAM6.fasta
Description

Entrez Gene Summary for ZSCAN4
The ZSCAN4 gene encodes a protein involved in telomere maintenance and with a key role in the critical feature of mouse embryonic stem (ES) cells, namely, defying cellular senescence and maintaining normal karyotype for many cell divisions in culture (Zalzman et al., 2010 (PubMed 20336070)).(supplied by OMIM, May 2010)

UniProtKB Summary for ZSCAN4
Function: Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ZSCAN4 ]
External IDs
Hgnc ID: 23709 EntrezGene ID: 201516 Ensembl ID: ENSG00000180532
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ZSCAN4 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
24840609The direct interaction between Zscan4 and Rap1 may explain how Zscan4 rapidly increases telomere length, yielding important information about the role of these proteins in telomere biology.2015-06-06
26403970ZSCAN4 indirectly interacts with TRF1 in cancer cells. We show that ZSCAN4 plays an important role independent of telomere maintenance pathways (telomerase positive and alternative pathway) or cell lineage.2016-04-30
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidenceZSCA4_HUMANZSCA2_MOUSE43311350.4426.15603064183004122E-27119
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




Showing 1-14 of 14 items.

gpmDB

Peptide SequenceEvidence LevelLog ENumber Of ObservationSpectraAccession IDProteotypicityAnnotation
SAFQQSQGPAVQRgreen-10.411ENSP00000321963Proteotypic
SAFQQSQGPAVQRgreen-10.411ENSP00000321963Proteotypic
IHTGEKPYTCPFCKgreen-10.151ENSP00000321963Proteotypic
IHTGEKPYTCPFCKgreen-10.151ENSP00000321963Proteotypic
TIFQCEPSENNLGSENSAFQQSQGPAVQRgreen-8.951ENSP00000321963Proteotypic
TIFQCEPSENNLGSENSAFQQSQGPAVQRgreen-8.951ENSP00000321963Proteotypic
TIFQCEPSENNLGSENSAFQQSQGPAVQRgreen-7.651ENSP00000321963Proteotypic
TIFQCEPSENNLGSENSAFQQSQGPAVQRgreen-7.651ENSP00000321963Proteotypic
NLGSENSAFQQSQGPAVQREEGISEFSRgreen-7.511ENSP00000321963Proteotypic
NLGSENSAFQQSQGPAVQREEGISEFSRgreen-7.511ENSP00000321963Proteotypic
TIFQCEPSENNLGSENSAFQQSQGPAVQRgreen-7.351ENSP00000321963Proteotypic
SAFQQSQGPAVQREEGISEFSRgreen-7.311ENSP00000321963Proteotypic
TIFQCEPSENNLGSENSAFQQSQGPAVQRgreen-7.351ENSP00000321963Proteotypic
SAFQQSQGPAVQREEGISEFSRgreen-7.311ENSP00000321963Proteotypic
Evidence File
/mnt/mpp/ms_data/Q8NAM6_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/Q8NAM6_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Proteomics DB

Evidence File
/mnt/mpp/ms_data/Q8NAM6_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB