CAPN12:Calpain-12

Gene Name
Calpain-12
Protein ID
Q6ZSI9
Chromosome ID
19
HPP Status
1
Protein Name
Calpain-12
Synonyms

calcium-activated neutral proteinase 12

calpain-12

CANP 12

Calcium-activated neutral proteinase 12

calpain 12

EC 3.4.22.-


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=CAPN12 ]
Chromosomal Position
19q13.2 | Start:38730187 End:38730187
Sequence
Q6ZSI9.fasta
Description

Entrez Gene Summary for CAPN12
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes a member of the calpain large subunit family. (provided by RefSeq, Jun 2012)

UniProtKB Summary for CAPN12
Function: Calcium-regulated non-lysosomal thiol-protease (By similarity)

Tocris Summary for CAPN12
Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals. This family contains 14 members with mu-calpain (calpain 1) and m-calpain (calpain 2) being the most well-characterized. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure. Calpains are regulated by Ca2+ concentration, phosphorylation, calpastatin and probably by altering their subcellular localization (limiting access to substrate). These endopeptidases have numerous functions including, but not limited to, remodeling of cytoskeletal attachments to the plasma membrane during cell fusion and cell motility, proteolytic modification of molecules in signal transduction pathways, degradation of enzymes controlling progression through the cell cycle, regulation of gene expression, substrate degradation in some apoptotic pathways, and an involvement in long-term potentiation. Perturbations in calpain activity have been associated in pathophysiological processes contributing to type II diabetes (calpain 10), Alzheimer's disease (calpain 1), gastric cancer (calpain 9) and muscular dystrophy (calpain 3).

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=CAPN12 ]
External IDs
Hgnc ID: 13249 EntrezGene ID: 147968 Ensembl ID: ENSG00000182472
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=CAPN12 ]
Reference Source
http://www.nextprot.org

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation



Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




Showing 1-6 of 6 items.

gpmDB

Peptide SequenceEvidence LevelLog ENumber Of ObservationSpectraAccession IDProteotypicityAnnotation
PYFPAGPDALGYDQLGPDSEKAKGVKgreen-11.301ENSP00000331636Proteotypic
PYFPAGPDALGYDQLGPDSEKAKGVKgreen-11.301ENSP00000331636Proteotypic
LALNAAGFHLNNQLTQTLTSRgreen-6.691ENSP00000331636Proteotypic
LALNAAGFHLNNQLTQTLTSRgreen-6.691ENSP00000331636Proteotypic
LALNAAGFHLNNQLTQTLTSRgreen-6.691ENSP00000331636Proteotypic
LALNAAGFHLNNQLTQTLTSRgreen-6.691ENSP00000331636Proteotypic
Evidence File
/mnt/mpp/ms_data/Q6ZSI9_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


MaxQB

Evidence File
/mnt/mpp/ms_data/Q6ZSI9_maxqb.txt
Reference
Christoph Schaab, Tamar Geiger, Gabriele Stoehr, Juergen Cox and Matthias Mann: "Analysis of high-accuracy, quantitative proteomics data in the MaxQB database", Mol Cell Proteomics 11 (2012) M111.014068.
http://maxqb.biochem.mpg.de/mxdb/ ">MaxQB


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/Q6ZSI9_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Showing 1-2 of 2 items.

Proteomics DB

Peptide SequenceSearch EngineScoreThreshold ScoreIdentification IDExperiment IDAnnotation
CTVLLSLIQRNRMaxquant136.9606121120932
KEDGEFWMELRMaxquant119.53012301506612991
Evidence File
/mnt/mpp/ms_data/Q6ZSI9_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB