CYP2A7:Cytochrome P450 2A7

Gene Name
Cytochrome P450 2A7
Protein ID
P20853
Chromosome ID
19
HPP Status
2
Protein Name
Cytochrome P450 2A7
Synonyms

CYP2A

CPA7

cytochrome P450, family 2, subfamily A, polypeptide 7

cytochrome P450 IIA4

cytochrome P450IIA4

CPAD

P450-IIA4

cytochrome P450 2A7

CYPIIA7

cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 7

Cytochrome P450 IIA4

EC 1.14.14.1


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=CYP2A7 ]
Chromosomal Position
19q13.2 | Start:40875439 End:40875439
Sequence
P20853.fasta
Description

Entrez Gene Summary for CYP2A7
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum; its substrate has not yet been determined. This gene, which produces two transcript variants, is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. (provided by RefSeq, Jul 2008)

UniProtKB Summary for CYP2A7
Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=CYP2A7 ]
External IDs
Hgnc ID: 2611 EntrezGene ID: 1549 Ensembl ID: ENSG00000198077
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=CYP2A7 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
11960914CYP2A6/2A7 and CYP2E1 expression in human oesophageal mucosa: regional and inter-individual variation in expression and relevance to nitrosamine metabolism2010-01-21
12325023Observational study of genotype prevalence. (HuGE Navigator)2008-03-13
16636685Observational study of genotype prevalence and genetic testing. (HuGE Navigator)2008-03-13
25710939CYP2A7 affects CYP2A6 expression by competing for miR-126* binding.2015-12-19
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation



Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




Showing 1-20 of 132 items.

gpmDB

Peptide SequenceEvidence LevelLog ENumber Of ObservationSpectraAccession IDProteotypicityAnnotation
FAIATLRDFGVGKgreen-13.2101ENSP00000301146Proteotypic
FAIATLRDFGVGKgreen-13.2101ENSP00000301146Proteotypic
HLPGPQQQAFKLLQGLEDFIAKgreen-12.5821ENSP00000301146Proteotypic
HLPGPQQQAFKLLQGLEDFIAKgreen-12.5821ENSP00000301146Proteotypic
IQEESGFLIEAIRgreen-12.081ENSP00000301146Proteotypic
IQEESGFLIEAIRgreen-12.081ENSP00000301146Proteotypic
IQEESGFLIEAIRgreen-12.081ENSP00000301146Proteotypic
IQEESGFLIEAIRgreen-12.081ENSP00000301146Proteotypic
TKMPYMEAVIHEIQRgreen-11.1921ENSP00000301146Proteotypic
TKMPYMEAVIHEIQRgreen-11.1921ENSP00000301146Proteotypic
STHGANIDPTFFLSRgreen-10.2121ENSP00000301146Proteotypic
STHGANIDPTFFLSRgreen-10.2121ENSP00000301146Proteotypic
TKMPYMEAVIHEIQRgreen-9.9921ENSP00000301146Proteotypic
TKMPYMEAVIHEIQRgreen-9.9921ENSP00000301146Proteotypic
TKMPYMEAVIHEIQRgreen-9.7921ENSP00000301146Proteotypic
TKMPYMEAVIHEIQRgreen-9.7921ENSP00000301146Proteotypic
HVVFATIPRgreen-9.53981ENSP00000301146Proteotypic
HVVFATIPRgreen-9.53981ENSP00000301146Proteotypic
TKMPYMEAVIHEIQRgreen-9.2921ENSP00000301146Proteotypic
TKMPYMEAVIHEIQRgreen-9.2921ENSP00000301146Proteotypic
Evidence File
/mnt/mpp/ms_data/P20853_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


Showing 1-20 of 29 items.

PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
HLPGPQQQAFKLLQGLEDFIAK4.32152773247029E-5,Mascot:expectation;53.49,Mascot:score;PXD003271_59955_1819_P20853_HLPGPQQQAFKLLQGLEDFIAKPXD003271;MR1095C.mgf;index=8293
HLPGPQQQAFKLLQGLEDFIAK4.32152773247029E-5,Mascot:expectation;53.49,Mascot:score;PXD003271_59955_1819_P20853_HLPGPQQQAFKLLQGLEDFIAKPXD003271;MR1095C.mgf;index=8293
HLPGPQQQAFKLLQGLEDFIAK4.32152773247029E-5,Mascot:expectation;53.49,Mascot:score;PXD003271_59955_1819_P20853_HLPGPQQQAFKLLQGLEDFIAKPXD003271;MR1095C.mgf;index=8293
HLPGPQQQAFKLLQGLEDFIAK4.32152773247029E-5,Mascot:expectation;53.49,Mascot:score;PXD003271_59955_1819_P20853_HLPGPQQQAFKLLQGLEDFIAKPXD003271;MR1095C.mgf;index=8293
HLPGPQQQAFKLLQGLEDFIAK4.32152773247029E-5,Mascot:expectation;53.49,Mascot:score;PXD003271_59955_1819_P20853_HLPGPQQQAFKLLQGLEDFIAKPXD003271;MR1095C.mgf;index=8293
HLPGPQQQAFKLLQGLEDFIAK44.95,Mascot:score;3.08771568788347E-4,Mascot:expectation;PXD003271_59955_1820_P20853_HLPGPQQQAFKLLQGLEDFIAKPXD003271;MR1095C.mgf;index=8293
HLPGPQQQAFKLLQGLEDFIAK44.95,Mascot:score;3.08771568788347E-4,Mascot:expectation;PXD003271_59955_1820_P20853_HLPGPQQQAFKLLQGLEDFIAKPXD003271;MR1095C.mgf;index=8293
HLPGPQQQAFKLLQGLEDFIAK44.95,Mascot:score;3.08771568788347E-4,Mascot:expectation;PXD003271_59955_1820_P20853_HLPGPQQQAFKLLQGLEDFIAKPXD003271;MR1095C.mgf;index=8293
HLPGPQQQAFKLLQGLEDFIAK44.95,Mascot:score;3.08771568788347E-4,Mascot:expectation;PXD003271_59955_1820_P20853_HLPGPQQQAFKLLQGLEDFIAKPXD003271;MR1095C.mgf;index=8293
HLPGPQQQAFKLLQGLEDFIAK44.95,Mascot:score;3.08771568788347E-4,Mascot:expectation;PXD003271_59955_1820_P20853_HLPGPQQQAFKLLQGLEDFIAKPXD003271;MR1095C.mgf;index=8293
HLPGPQQQAFKLLQGLEDFIAK42.13,Mascot:score;5.91067805031149E-4,Mascot:expectation;PXD003271_59955_1821_P20853_HLPGPQQQAFKLLQGLEDFIAKPXD003271;MR1095C.mgf;index=8293
HLPGPQQQAFKLLQGLEDFIAK42.13,Mascot:score;5.91067805031149E-4,Mascot:expectation;PXD003271_59955_1821_P20853_HLPGPQQQAFKLLQGLEDFIAKPXD003271;MR1095C.mgf;index=8293
HLPGPQQQAFKLLQGLEDFIAK42.13,Mascot:score;5.91067805031149E-4,Mascot:expectation;PXD003271_59955_1821_P20853_HLPGPQQQAFKLLQGLEDFIAKPXD003271;MR1095C.mgf;index=8293
HLPGPQQQAFKLLQGLEDFIAK42.13,Mascot:score;5.91067805031149E-4,Mascot:expectation;PXD003271_59955_1821_P20853_HLPGPQQQAFKLLQGLEDFIAKPXD003271;MR1095C.mgf;index=8293
HLPGPQQQAFKLLQGLEDFIAK42.13,Mascot:score;5.91067805031149E-4,Mascot:expectation;PXD003271_59955_1821_P20853_HLPGPQQQAFKLLQGLEDFIAKPXD003271;MR1095C.mgf;index=8293
HLPGPQQQAFKLLQGLEDFIAK5.92430357041928E-4,Mascot:expectation;42.12,Mascot:score;PXD003271_59955_1822_P20853_HLPGPQQQAFKLLQGLEDFIAKPXD003271;MR1095C.mgf;index=8293
HLPGPQQQAFKLLQGLEDFIAK5.92430357041928E-4,Mascot:expectation;42.12,Mascot:score;PXD003271_59955_1822_P20853_HLPGPQQQAFKLLQGLEDFIAKPXD003271;MR1095C.mgf;index=8293
HLPGPQQQAFKLLQGLEDFIAK5.92430357041928E-4,Mascot:expectation;42.12,Mascot:score;PXD003271_59955_1822_P20853_HLPGPQQQAFKLLQGLEDFIAKPXD003271;MR1095C.mgf;index=8293
HLPGPQQQAFKLLQGLEDFIAK5.92430357041928E-4,Mascot:expectation;42.12,Mascot:score;PXD003271_59955_1822_P20853_HLPGPQQQAFKLLQGLEDFIAKPXD003271;MR1095C.mgf;index=8293
HLPGPQQQAFKLLQGLEDFIAK5.92430357041928E-4,Mascot:expectation;42.12,Mascot:score;PXD003271_59955_1822_P20853_HLPGPQQQAFKLLQGLEDFIAKPXD003271;MR1095C.mgf;index=8293
Evidence File
/mnt/mpp/ms_data/P20853_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Proteomics DB

Evidence File
/mnt/mpp/ms_data/P20853_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB