PTGER1:Prostaglandin E2 receptor EP1 subtype

Gene Name
Prostaglandin E2 receptor EP1 subtype
Protein ID
P34995
Chromosome ID
19
HPP Status
2
Protein Name
Prostaglandin E2 receptor EP1 subtype
Synonyms

Prostanoid EP1 receptor

prostaglandin E receptor 1 (subtype EP1), 42kD

PGE receptor, EP1 subtype

prostaglandin E receptor 1, subtype EP1

prostaglandin E receptor 1 (subtype EP1), 42kDa

PGE receptor EP1 subtype

prostanoid EP1 receptor

PGE2 receptor EP1 subtype

prostaglandin E2 receptor EP1 subtype

EP1


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=PTGER1 ]
Chromosomal Position
19p13.12 | Start:14472466 End:14472466
Sequence
P34995.fasta
Description

Entrez Gene Summary for PTGER1
The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin. (provided by RefSeq, Jul 2008)

UniProtKB Summary for PTGER1
Function: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues

Tocris Summary for PTGER1
Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2, prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which the other prostaglandins are synthesized. Prostanoid receptors are a family of nine G-protein-coupled receptors that have distinct tissue distributions and actions. EP receptors (EP1-4) are a diverse group of prostanoid receptors. EP1 receptors are restricted to the kidney lung and stomach and induce smooth muscle contraction. EP2 and EP4 couple to Galphas and induce smooth muscle relaxation. EP3 is an inhibitory receptor that prevents smooth muscle relaxation.

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=PTGER1 ]
External IDs
Hgnc ID: 9593 EntrezGene ID: 5731 Ensembl ID: ENSG00000160951
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=PTGER1 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
1160156Functional analysis of the mouse counterpart.2003-11-18
12642666Functional analysis of the mouse counterpart.2003-11-18
12788892Agonists of EP(1) and EP(2) significantly increased aromatase activity levels, which were decreased by the corresponding antagonists. Generally reflective of changes in aromatase protein expression and the pattern of mRNA expression.2010-01-21
12841871the combined effects of EP(1) and EP(4) antagonists on spontaneous polyp formation in APC knockout mice2010-01-21
14562138Human corpus cavernosum and cultured smooth muscle cells express EP1, EP2 and EP3 receptors.2010-01-21
14744769COX-2 up-regulates VEGF-C and promotes lymphangiogenesis in human lung adenocarcinoma via the EP(1)/Src/HER-2/Neu signaling pathway.2010-01-21
15886234PGE2 stimulates extravillous trophoblast migration by signaling through EP1 receptors, increasing [Ca2+]i, and activating calpain2010-01-21
16393343EP1 receptor level increase in sensory neurones, and macrophage infiltration, appears to precede increased Cox-2 expression by macrophages in nerve injury2010-01-21
16670773EP(1) does not appear to have a significant direct effect on airway tone but acts as a modulator of the beta(2)AR, altering G(alphas) coupling via steric interactions imposed by the EP(1):beta(2)AR heterodimeric signaling complex2010-01-21
17496729Observational study of gene-disease association. (HuGE Navigator)2008-03-13
17525067participates in placentation through EVT invasion by up-regulating PGE2 production and PGE2 receptor expression in first trimester extravillous trophoblasts2010-01-21
17611676Results show co-expression of cyclooxygenase-2 and prostaglandin E2 receptors EP1, 2 and 4 in non-small cell lung cancer cells concomitant with the synthesis of PGE2.2010-01-21
17877755Observational study of gene-disease association. (HuGE Navigator)2008-03-13
17906615Expression of EP1 is frequently seen in human breast cancers. Nuclear expression of EP1 correlates with good prognosis markers like node negative status and progesterone receptor expression.2010-01-21
18516068Of the 4 EP receptor subtypes, smooth muscle cells in the human pulmonary vein express the EP4 and EP1 receptor subtypes2010-01-21
19064572Observational study and meta-analysis of gene-disease association. (HuGE Navigator)2009-01-11
19336370Observational study of gene-disease association. (HuGE Navigator)2009-04-22
19625175The EP1 subtype of prostaglandin E2 receptor has a role in keratinocyte differentiation and expression in non-melanoma skin cancer.2010-03-08
19913121Observational study of gene-disease association. (HuGE Navigator)2010-09-15
20178602Prostaglandin E2 enhances the migration of chondrosarcoma cells by increasing alpha2beta1 integrin expression through the EP1/PLC/PKCalpha/c-Src/NF-kappaB signal transduction pathway.2010-05-31
20452482Observational study of gene-disease association. (HuGE Navigator)2010-06-30
20587336Observational study of gene-disease association. (HuGE Navigator)2010-09-15
20628086Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)2010-09-15
20647315the PGE(2) and EP1 interaction enhanced migration of oral cancer cells through an increase in ICAM-1 production2010-10-23
20673868Observational study of gene-disease association. (HuGE Navigator)2010-09-15
20858737EP1 functions as a suppressor of tumor metastasis; loss of nuclear EP1 is associated with poorer overall survival and may contribute to disparities in outcome in different populations.2011-09-17
21052031Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)2010-12-05
21447366We could not find an association of EP1 gene with suicide in the Japanese population2011-09-17
21813027Data indicate that not only Cox-2 but also EP1 and EP3 could be important targets for chemosensitization and inhibition of metastasis in breast cancers that are resistant to chemotherapy.2012-02-11
22110249A novel dendritic cell(DC) progenitor regulatory pathway in which PGE(2) signaling through EP1/EP3 receptors regulates Flt3 expression and downstream STAT3 activation and survivin expression, required for optimal progenitor survival and differentiation.2012-05-05
22162473The roles of prostaglandin EP 1 and 3 receptors in the control of human myometrial contractility.2012-04-14
22276108Neuroblastoma express all four forms of PGE(2) receptors.2012-06-09
22474323new role for the EP(1) receptor in resolving inflammation through down-regulation of COX-2.2012-07-28
22555372Suggest that the anti-carcinogenic effects of EGCG in hepatocellular carcinoma might be mediated, at least partially, through the suppressing EP(1) receptor expression and PGE(2) production.2012-09-01
22924768PGE(2) -mediated NF-kappaB activation by simultaneous stimulation of EP(1) and EP(4) receptors induces maximal IL-8 promoter activation and IL-8 mRNA and protein induction2013-07-06
23494562PGE2-enhanced MMP2 expression is mediated through EP1 receptors and calcium signaling pathway-induced CREB phosphorylation in human cholangiocarcinoma cells.2013-11-16
23525457Our study suggests that the PGE EP1 receptor regulates FAK phosphorylation by activating the PKC/c-Src and EGFR signal pathways, which may coordinately regulate adhesion and migration in HCC2013-11-02
23842570through complex formation with D1, EP1 signaling directs the D1 receptor through G(betagamma) to be coupled to AC7.2013-11-30
24333447COX-1, H446K' is significantly more sensitive to downregulation by EP . Together these data suggest that distinctive ubiquitination of COX-1 and COX-2 may be responsible for their different sensitivity to EP -mediated degradation.2014-03-15
24614038A transient interaction between COX-2 and EP1 constitutes a feedback loop whereby an increase in COX-2 expression elevates EP1.2016-04-02
25289898NF-kappaB inhibitor suppressed 17-PT-PGE2-mediated FoxC2 upregulation. Immunohistochemistry showed p65, FoxC2, EP1 receptor and beta1-integrin were all highly expressed in the HCC cases2015-11-07
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


KEGG Pathways

Pathway IDDatabase NamePathway Name
hsa04020KEGG PATHWAYCalcium signaling pathway
hsa04080KEGG PATHWAYNeuroactive ligand-receptor interaction
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/P34995_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/P34995_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Proteomics DB

Evidence File
/mnt/mpp/ms_data/P34995_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB