BHLHE22:Class E basic helix-loop-helix protein 22

Gene Name
Class E basic helix-loop-helix protein 22
Protein ID
Q8NFJ8
Chromosome ID
8
HPP Status
2
Protein Name
Class E basic helix-loop-helix protein 22
Synonyms

CAGL85

bHLHb5

bHLHe22

Class B basic helix-loop-helix protein 5

TNRC20

trinucleotide repeat-containing gene 20 protein

BETA3

trinucleotide repeat containing 20

class E basic helix-loop-helix protein 22

Trinucleotide repeat-containing gene 20 protein

Beta3

basic helix-loop-helix family, member e22

BHLHB5

basic helix-loop-helix domain containing, class B, 5

class B basic helix-loop-helix protein 5


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=BHLHE22 ]
Chromosomal Position
8q12.3 | Start:64580367 End:64580367
Sequence
Q8NFJ8.fasta
Description

Entrez Gene Summary for BHLHE22
BHLHE22 belongs to the basic helix-loop-helix (bHLH) family of transcription factors that regulate cell fate determination, proliferation, and differentiation. These proteins function as dimers and bind to an E-box DNA sequence (CANNTG). BHLHE22 is expressed exclusively in the central nervous system and retina (Xu et al., 2002 (PubMed 12213201)).(supplied by OMIM, Jul 2010)

UniProtKB Summary for BHLHE22
Function: Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA (By similarity)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=BHLHE22 ]
External IDs
Hgnc ID: 11963 EntrezGene ID: 27319 Ensembl ID: ENSG00000180828
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=BHLHE22 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
12213201Segregates with Duane syndrome. Brain-specific expression with the highest abundance in the cerebellum.2010-01-21
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation



Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/Q8NFJ8_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/Q8NFJ8_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Showing 1-1 of 1 item.

Proteomics DB

Evidence File
/mnt/mpp/ms_data/Q8NFJ8_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB