HTRA4:Serine protease HTRA4

Gene Name
Serine protease HTRA4
Protein ID
P83105
Chromosome ID
8
HPP Status
1
Protein Name
Serine protease HTRA4
Synonyms

High-temperature requirement factor A4

serine protease HTRA4

high-temperature requirement factor A4

HtrA serine peptidase 4

probable serine protease HTRA4

EC 3.4.21.-


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=HTRA4 ]
Chromosomal Position
8p11.22 | Start:38974164 End:38974164
Sequence
P83105.fasta
Description

Entrez Gene Summary for HTRA4
This gene encodes a member of the HtrA family of proteases. The encoded protein contains a putative signal peptide, an insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domain and a PDZ domain. Based on studies on other related family members, this enzyme may function as a secreted oligomeric chaperone protease to degrade misfolded secretory proteins. Other human HtrA proteins have been implicated in arthritis, tumor suppression, unfolded stress response, apoptosis, and aging. (provided by RefSeq, Oct 2008)

UniProtKB Summary for HTRA4
Function: Serine protease (Probable)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=HTRA4 ]
External IDs
Hgnc ID: 26909 EntrezGene ID: 203100 Ensembl ID: ENSG00000169495
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=HTRA4 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
12408815FLJ90724 or HTRA4 is a member of the HtrA family of proteases2004-12-28
22778138study reveals a novel function of GCM1 and HtrA4 in regulation of trophoblast invasion and that abnormal HrtA4 expression may contribute to shallow trophoblast invasion in preeclampsia2012-11-24
22964307Data suggest that increased HtrA4 (and HtrA1) in placenta tissues may be involved in onset of pre-eclampsia; elevated level of HtrA4 (but not HtrA1) in sera has potential as biomarker for pre-eclampsia.2013-03-23
25002585Conditioned media from these two cell lines after decidualization treatment suppress HtrA4-expressing JAR cell invasion in an HtrA1- or HtrA3-dependent manner.2014-12-20
25946029HtrA4 represents a novel placenta-specific serine protease that is altered specifically in early-onset preeclampsia with potential causal roles in endothelial dysfunction and disease development.2015-10-17
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation



Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




Showing 1-20 of 22 items.

gpmDB

Peptide SequenceEvidence LevelLog ENumber Of ObservationSpectraAccession IDProteotypicityAnnotation
IESNAELPVLMLGRgreen-15.061ENSP00000305919Proteotypic
IESNAELPVLMLGRgreen-15.061ENSP00000305919Proteotypic
CPALPTCALGTTPVFDLCRgreen-13.781ENSP00000305919Proteotypic
CPALPTCALGTTPVFDLCRgreen-13.781ENSP00000305919Proteotypic
CPALPTCALGTTPVFDLCRgreen-10.781ENSP00000305919Proteotypic
CPALPTCALGTTPVFDLCRgreen-10.781ENSP00000305919Proteotypic
CPALPTCALGTTPVFDLCRgreen-10.081ENSP00000305919Proteotypic
CPALPTCALGTTPVFDLCRgreen-10.081ENSP00000305919Proteotypic
IESNAELPVLMLGRgreen-8.161ENSP00000305919Proteotypic
IESNAELPVLMLGRgreen-8.161ENSP00000305919Proteotypic
CPALPTCALGTTPVFDLCRgreen-8.081ENSP00000305919Proteotypic
CPALPTCALGTTPVFDLCRgreen-8.081ENSP00000305919Proteotypic
AGEFVVALGSPFSLQNTATAGIVSTKQRgreen-7.911ENSP00000305919Proteotypic
AGEFVVALGSPFSLQNTATAGIVSTKQRgreen-7.911ENSP00000305919Proteotypic
CPALPTCALGTTPVFDLCRgreen-7.881ENSP00000305919Proteotypic
CPALPTCALGTTPVFDLCRgreen-7.881ENSP00000305919Proteotypic
CPALPTCALGTTPVFDLCRgreen-7.681ENSP00000305919Proteotypic
CPALPTCALGTTPVFDLCRgreen-7.681ENSP00000305919Proteotypic
GSPFSLQNTATAGIVSTKgreen-6.611ENSP00000305919Proteotypic
GSPFSLQNTATAGIVSTKgreen-6.611ENSP00000305919Proteotypic
Evidence File
/mnt/mpp/ms_data/P83105_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


Showing 1-2 of 2 items.

PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
LDLAVIK0.00209006264540586,Mascot:expectation;34.0,Mascot:score;PXD001694_43450_5409_P83105_LDLAVIKPXD001694;JNU_20140426 b1_MGFPeaklist.mgf;index=35365
YEAVVKDIDLKLDLAVIK11.83,Spectrum Mill peptide score;PRD000053_8876_571_P83105_YEAVVKDIDLKLDLAVIKPRD000053;PRIDE_Exp_Complete_Ac_8876.xml;spectrum=571
Evidence File
/mnt/mpp/ms_data/P83105_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Showing 1-20 of 35 items.

Proteomics DB

Peptide SequenceSearch EngineScoreThreshold ScoreIdentification IDExperiment IDAnnotation
CPALPTCALGTTPVFDLCRMaxquant362.2201247904825279
AGEFVVALGSPFSLQNTATAGIVSTKMaxquant324.1501247774210279
IESNAELPVLMLGRMaxquant261.3501250247847279
LHTQPSCPAVCQPTRMaxquant258.2301252099045279
VAPSVVHVQLWGRMaxquant251.301256493821279
EVCGGAQGQPCAPGLQCLQPLRPGFPSTCGCPTLGGAVCGSDRRMaxquant246.3401248206701279
NQQWIEVVLQNGARMaxquant244.5801254158462279
ALDSDSLSMAVLRMaxquant225.1301247804229279
LVPVYSGSGFIVSEDGLIITNAHVVRMaxquant223.9701253145606279
VTDGISFAIPSDRMaxquant222.7301256626155279
YLGLQMLSLTVPLSEELKMaxquant221.4701256722884279
LVPVYSGSGFIVSEDGLIITNAHVVRMascot228.17271246246929279
IESNAELPVLMLGRMaxquant203.3201250247827279
VVEGTAAQSSGLRMaxquant188.0901256638451279
EVCGGAQGQPCAPGLQCLQPLRPGFPSTCGCPTLGGAVCGSDRRMascot164.41241246336953279
DIDLKLDLAVIKMaxquant176.9101247964567279
LHTQPSCPAVCQPTRMaxquant174.5901252099041279
MHYPDFPDVSSGVYVCKMaxquant174.1701253377827279
MHYPDFPDVSSGVYVCKMaxquant170.9101253377824279
DHDVIVNINGKPITTTTDVVKMaxquant165.4101247960516279
Evidence File
/mnt/mpp/ms_data/P83105_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB