EBF2:Transcription factor COE2

Gene Name
Transcription factor COE2
Protein ID
Q9HAK2
Chromosome ID
8
HPP Status
2
Protein Name
Transcription factor COE2
Synonyms

early B-cell factor 2

Early B-cell factor 2

EBF-2

COE2

transcription factor COE2

O/E-3

OE-3

Collier, Olf and EBF 2

metencephalon-mesencephalnon-olfactory transcription factor 1

OLF-1/EBF-LIKE 3


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=EBF2 ]
Chromosomal Position
8p21.2 | Start:25841730 End:25841730
Sequence
Q9HAK2.fasta
Description

Entrez Gene Summary for EBF2
The protein encoded by this gene belongs to the COE (Collier/Olf/EBF) family of non-basic, helix-loop-helix transcription factors that have a well conserved DNA binding domain. The COE family proteins play an important role in variety of developmental processes. Studies in mouse suggest that this gene may be involved in the differentiation of osteoblasts. (provided by RefSeq, Oct 2011)

UniProtKB Summary for EBF2
Function: Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=EBF2 ]
External IDs
Hgnc ID: 19090 EntrezGene ID: 64641 Ensembl ID: ENSG00000221818
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=EBF2 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
19671856EBF2 as a mediator of osteoprotegerin inhibition to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis.2010-01-21
19913121Observational study of gene-disease association. (HuGE Navigator)2010-09-15
20379614Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)2010-06-30
20628086Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)2010-09-15
20734064Observational study of gene-disease association. (HuGE Navigator)2010-12-05
25002143Blnc1 forms a ribonucleoprotein complex with transcription factor EBF2 to stimulate the thermogenic gene program. Further, Blnc1 itself is a target of EBF2, thereby forming a feedforward regulatory loop to drive adipogenesis toward thermogenic phenotype.2014-10-18
26686553Novel inguinal hernia susceptibility genes are identified as EFEMP1, WT1, EBF2 and ADAMTS6.2016-05-14
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation



Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




Showing 1-1 of 1 item.

MaxQB

Peptide SequenceSearch EngineBest ScoreBest Evidence IDBest Raw File IDBest Msms ScanAnnotation
TAFVDFVENDKEQGNEKMaxQuant121.99674743420101227_Velos1_TaGe_SA_HEK293_0515032
Evidence File
/mnt/mpp/ms_data/Q9HAK2_maxqb.txt
Reference
Christoph Schaab, Tamar Geiger, Gabriele Stoehr, Juergen Cox and Matthias Mann: "Analysis of high-accuracy, quantitative proteomics data in the MaxQB database", Mol Cell Proteomics 11 (2012) M111.014068.
http://maxqb.biochem.mpg.de/mxdb/ ">MaxQB


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/Q9HAK2_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Showing 1-1 of 1 item.

Proteomics DB

Peptide SequenceSearch EngineScoreThreshold ScoreIdentification IDExperiment IDAnnotation
TAFVDFVENDKEQGNEKMaxquant123.1401523768122
Evidence File
/mnt/mpp/ms_data/Q9HAK2_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB