ABRA:Actin-binding Rho-activating protein
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Gene Name
Actin-binding Rho-activating protein |
Protein ID
Q8N0Z2 |
Chromosome ID
8 |
HPP Status
1 |
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Protein Name
Actin-binding Rho-activating protein |
Synonyms
STARS striated muscle activator of Rho-dependent signaling actin-binding Rho activating protein "striated muscle activator of Rho-dependent signaling" actin-binding Rho-activating protein Striated muscle activator of Rho-dependent signaling [Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ABRA  ] |
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Chromosomal Position
8q23.1 | Start:106759483 End:106759483 |
Sequence
Q8N0Z2.fasta |
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Description
UniProtKB Summary for ABRAFunction: Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling (By similarity) [Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ABRA ] |
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External IDs
Hgnc ID: 30655 EntrezGene ID: 137735 Ensembl ID: ENSG00000174429 [Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ABRA ] |
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Reference Source
http://www.nextprot.org |
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Gene Reference Into Function (GeneRIF)
| PubMed ID | GeneRIF Text | Last Update |
|---|---|---|
| 15798203 | STARS activates serum response factor by inducing the nuclear translocation of myocardin-related transcription factors . | 2010-01-21 |
| 17415416 | Modulates the responsiveness of the heart to stress signaling by functioning as a cytoskeletal intermediary between human and transgenic myocyte enhancer factor-2 and serum response factor. | 2010-01-21 |
| 19255118 | STARS signalling pathway is responsive to changes in skeletal muscle loading and appears to play a role in both human skeletal muscle hypertrophy and atrophy | 2010-01-21 |
| 21486805 | STARS signalling pathway is upregulated in response to acute endurance exercise and suggest suggest a novel role co-ordination of PGC-1alpha-induced upregulation of the fat oxidative gene, CPT-1beta. | 2011-08-13 |
| 23753523 | These results show that resistance exercise provides an acute stimulation of the STARS pathway that is contraction mode dependent. | 2014-03-01 |
| Reference http://www.ncbi.nlm.nih.gov/gene/about-generif ftp://ftp.ncbi.nih.gov/gene/GeneRIF/ | ||
OMICSDI Browser
Relevant citations within the PubMed literature
Putative/known Functions
Localisation
Homologues, Orthologues, Paralogues and Family
Sequence Similarity and Functional Annotation
Sequence Similarity
| Db Name | Query Uni | Subject Uni | Sequence Length | Alignment Length | Identity | Coverage | Mismatches | Gap Openings | Query Start | Query End | Subject Start | Subject End | Evalue | Bit Score |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Reviewed non-human mammalian with experimental evidence | ABRA_HUMAN | ABRA_MOUSE | 381 | 381 | 79 | 100 | 74 | 1 | 1 | 381 | 1 | 375 | 5E-172 | 600 |
| Reference Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83. | ||||||||||||||