ABRA:Actin-binding Rho-activating protein

Gene Name
Actin-binding Rho-activating protein
Protein ID
Q8N0Z2
Chromosome ID
8
HPP Status
1
Protein Name
Actin-binding Rho-activating protein
Synonyms

STARS

striated muscle activator of Rho-dependent signaling

actin-binding Rho activating protein

"striated muscle activator of Rho-dependent signaling"

actin-binding Rho-activating protein

Striated muscle activator of Rho-dependent signaling


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ABRA ]
Chromosomal Position
8q23.1 | Start:106759483 End:106759483
Sequence
Q8N0Z2.fasta
Description

UniProtKB Summary for ABRA
Function: Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling (By similarity)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ABRA ]
External IDs
Hgnc ID: 30655 EntrezGene ID: 137735 Ensembl ID: ENSG00000174429
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ABRA ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
15798203STARS activates serum response factor by inducing the nuclear translocation of myocardin-related transcription factors .2010-01-21
17415416Modulates the responsiveness of the heart to stress signaling by functioning as a cytoskeletal intermediary between human and transgenic myocyte enhancer factor-2 and serum response factor.2010-01-21
19255118STARS signalling pathway is responsive to changes in skeletal muscle loading and appears to play a role in both human skeletal muscle hypertrophy and atrophy2010-01-21
21486805STARS signalling pathway is upregulated in response to acute endurance exercise and suggest suggest a novel role co-ordination of PGC-1alpha-induced upregulation of the fat oxidative gene, CPT-1beta.2011-08-13
23753523These results show that resistance exercise provides an acute stimulation of the STARS pathway that is contraction mode dependent.2014-03-01
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidenceABRA_HUMANABRA_MOUSE38138179100741138113755E-172600
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/Q8N0Z2_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/Q8N0Z2_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Showing 1-1 of 1 item.

Proteomics DB

Peptide SequenceSearch EngineScoreThreshold ScoreIdentification IDExperiment IDAnnotation
SDSVDTEDSGYGGEAEERPEQDGVQVAVVRMaxquant140.45012366710223061
Evidence File
/mnt/mpp/ms_data/Q8N0Z2_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB