EGR3:Early growth response protein 3

Gene Name
Early growth response protein 3
Protein ID
Chromosome ID
HPP Status
Protein Name
Early growth response protein 3


early growth response 3


Zinc finger protein pilot

"zinc finger protein pilot"

zinc finger protein pilot

early growth response protein 3

[Reference: ]
Chromosomal Position
8p21.3 | Start:22687659 End:22687659

Entrez Gene Summary for EGR3
This gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controling biological rhythm. It may also play a role in a wide variety of processes including muscle development, lymphocyte development, endothelial cell growth and migration, and neuronal development. Alternative splicing results in multiple transcript variants encoding distinct isoforms.(provided by RefSeq, Dec 2010)

UniProtKB Summary for EGR3
Function: Probable transcription factor involved in muscle spindle development

[Reference: ]
External IDs
Hgnc ID: 3240 EntrezGene ID: 1960 Ensembl ID: ENSG00000179388
[Reference: ]
Reference Source

Gene Reference Into Function (GeneRIF)

PubMed IDGeneRIF TextLast Update
11909874HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoter2010-01-21
14525795Vascularendothelial growth factor induces expression of NR4A nuclear receptors and Egr3 via KDR and KDR-mediated signaling mechanisms.2010-01-21
15171706data suggest that Egr3 is a target for the estrogen receptor alpha2010-01-21
15173177Egr-2 and Egr-3 transcription is enhanced by Hepatitis B virus X protein, which induces fasL gene expression2010-01-21
17360599These findings support the previous genetic association of altered calcineurin signaling with schizophrenia pathogenesis and identify EGR3 as a compelling susceptibility gene.2010-01-21
18059339findings indicate that Egr3 has an essential downstream role in VEGF-mediated endothelial functions leading to angiogenesis and may have particular relevance for adult angiogenic processes involved in vascular repair and neovascular disease2010-01-21
19124717Enforced expression of Egr3 transgene, from the CD2 antigen promoter, facilitates development of RAG2-deficient double-negative (DN) stage 3 thymocytes to the DN4 stage and subsequently to the double-positive stage of development.2010-01-21
19453261Observational study of gene-disease association. (HuGE Navigator)2009-06-24
19822898Data show that VEGFR1 promoter binding sites for ELF-1, CREB and EGR-1/3 play a positive role in gene transcription in endothelial cells.2010-02-15
19839995Observational study of gene-disease association. (HuGE Navigator)2009-12-02
19965691Egr-3 is a critical determinant of VEGF signaling in activated endothelial cells2010-04-19
20144677Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)2010-04-07
20379146Observational study and genome-wide association study of gene-disease association and gene-environment interaction. (HuGE Navigator)2010-06-30
20506119Results suggest that in many cells of neuroectodermal and epithelial origin EGR1, EGR2, and EGR3 activate NAB2 transcription which is in turn repressed by NAB2, thus establishing a negative feedback loop.2011-02-26
20537399Observational study of gene-disease association. (HuGE Navigator)2010-06-30
20537399This study demoistrated that ERG3 are not genetic risk factors for schizophrenia in japanese.2011-03-05
20634891Observational study of gene-disease association. (HuGE Navigator)2010-09-15
20687139Observational study of gene-disease association. (HuGE Navigator)2010-09-15
20687139SNP rs35201266 in intron 1 of the EGR3 gene showed a significant association with schizophrenia2011-01-15
21421043EGR3 bound to the TREM-1 promoter.2011-12-10
22276163Study supports the association of EGR3 with schizophrenia in Han Chinese sample.2012-06-09
22370066EGR3, a gene that translates environmental stimuli into long-term changes in the brain, may be associated with risk for child bipolar disorder 1.2012-11-24
22425949EGR3 gene may play an important role in schizophrenia susceptibility2012-05-12
23342084Egr3 mRNA expression reveals that Egr3 mRNA expression is increased in tumor cells of non-relapsed samples compared to normal prostate cells, but is significantly lower in relapsed samples compared to non-relapse.2013-08-03
23460371Decreased EGR3 expression might play a critical role in the differentiation, proliferation, metastasis and progression of gastric cancer cells.2014-04-19
23485457EGR2 and EGR3 are regulated by NFkappaB and MAPK signalling pathways downstream of TNFalpha stimulation in breast adipose fibroblasts, and this in turn is upstream of CYP19A1 transcription via PI.42013-05-25
23904169Our results suggest that Egr-3 is a transcription factor associated with TGF-beta1 expression and in vivo regulatory activity2013-11-16
23906810These results provide the first evidence that Egr-3, is up-regulated in scleroderma and is necessary and sufficient for profibrotic responses.2014-04-26
23935197These data suggest that type I IFN stimulation induces a rapid recruitment of a repressive Egr3/Nab1 complex that silences transcription from the ifngr1 promoter.2013-11-16
23962955Genetic variation in EGR3 may affect prefrontal function through neurodevelopment2014-08-09
24886494Data shows association of Egr3 genetic polymorphisms and coronary artery disease in the Uygur and Han of China2014-11-29
25633035EGR3 promotes excessive production of IL6 and IL8 observed during the progression of prostate cancer.2015-05-02
26474411These findings support previously reported associations between EGR3 and schizophrenia.2016-06-04


Relevant citations within the PubMed literature


Putative/known Functions


Homologues, Orthologues, Paralogues and Family

Sequence Similarity and Functional Annotation

Post Translational Modifications

Protein Protein Interactions

Best Available Mass Spectra without FDR


Evidence File
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803. ">Global Proteome Machine Database - THE GPM


Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456. ">PRIDE Archive

Proteomics DB

Evidence File
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7. ">Proteomics DB