KLF7:Krueppel-like factor 7

Gene Name
Krueppel-like factor 7
Protein ID
Chromosome ID
HPP Status
Protein Name
Krueppel-like factor 7

Krueppel-like factor 7

Ubiquitous krueppel-like factor

ubiquitous Kruppel-like transcription factor


Kruppel-like factor 7 (ubiquitous)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=KLF7 ]
Chromosomal Position
2q33.3 | Start:207074137 End:207074137

Entrez Gene Summary for KLF7
The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Aug 2012)

UniProtKB Summary for KLF7
Function: Transcriptional activator. Binds in vitro to the CACCC motif of the beta-globin promoter and to the SP1 recognition sequence

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=KLF7 ]
External IDs
Hgnc ID: 6350 EntrezGene ID: 8609 Ensembl ID: ENSG00000118263
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=KLF7 ]
Reference Source

Gene Reference Into Function (GeneRIF)

PubMed IDGeneRIF TextLast Update
14644156KLF7 was upregulated by morphine at both the transcriptional and the translational levels, promoting cell growth up to day 42010-01-21
15937668Observational study of gene-disease association. (HuGE Navigator)2008-03-13
15937668The gene encoding KLF7 is a novel candidate for conferring genetic susceptibility to type 2 diabetes.2010-01-21
16339272KLF7 may contribute to the pathogenesis of type 2 diabetes through an impairment of insulin biosynthesis and secretion in pancreatic beta-cells and a reduction of insulin sensitivity in peripheral tissues.2010-01-21
19147600Observational study of gene-disease association. (HuGE Navigator)2009-02-11
19147600We identified a novel association between the minor A-allele of KLF7 and protection against obesity in the Danish population2010-01-21
24207122a dominant mutation in FBXO38 causes adult-onset, progressive spinal muscular atrophy with calf predominance2014-01-04


Relevant citations within the PubMed literature


Putative/known Functions


Homologues, Orthologues, Paralogues and Family

Sequence Similarity and Functional Annotation

Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidenceKLF7_HUMANKLF3_MOUSE3029077.7829.82002133022533424E-43171
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
KLF7_HUMANIPR013087GO:0003676DomainZinc finger C2H2-type/integrase DNA-binding domainMolecular Functionnucleic acid binding
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications

Protein Protein Interactions

Best Available Mass Spectra without FDR


Evidence File
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


Evidence File
Christoph Schaab, Tamar Geiger, Gabriele Stoehr, Juergen Cox and Matthias Mann: "Analysis of high-accuracy, quantitative proteomics data in the MaxQB database", Mol Cell Proteomics 11 (2012) M111.014068.
http://maxqb.biochem.mpg.de/mxdb/ ">MaxQB


Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive

Proteomics DB

Evidence File
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB