KLF7:Krueppel-like factor 7

Gene Name
Krueppel-like factor 7
Protein ID
O75840
Chromosome ID
2
HPP Status
2
Protein Name
Krueppel-like factor 7
Synonyms

Krueppel-like factor 7

Ubiquitous krueppel-like factor

ubiquitous Kruppel-like transcription factor

UKLF

Kruppel-like factor 7 (ubiquitous)


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=KLF7 ]
Chromosomal Position
2q33.3 | Start:207074137 End:207074137
Sequence
O75840.fasta
Description

Entrez Gene Summary for KLF7
The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Aug 2012)

UniProtKB Summary for KLF7
Function: Transcriptional activator. Binds in vitro to the CACCC motif of the beta-globin promoter and to the SP1 recognition sequence

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=KLF7 ]
External IDs
Hgnc ID: 6350 EntrezGene ID: 8609 Ensembl ID: ENSG00000118263
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=KLF7 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
14644156KLF7 was upregulated by morphine at both the transcriptional and the translational levels, promoting cell growth up to day 42010-01-21
15937668Observational study of gene-disease association. (HuGE Navigator)2008-03-13
15937668The gene encoding KLF7 is a novel candidate for conferring genetic susceptibility to type 2 diabetes.2010-01-21
16339272KLF7 may contribute to the pathogenesis of type 2 diabetes through an impairment of insulin biosynthesis and secretion in pancreatic beta-cells and a reduction of insulin sensitivity in peripheral tissues.2010-01-21
19147600Observational study of gene-disease association. (HuGE Navigator)2009-02-11
19147600We identified a novel association between the minor A-allele of KLF7 and protection against obesity in the Danish population2010-01-21
24207122a dominant mutation in FBXO38 causes adult-onset, progressive spinal muscular atrophy with calf predominance2014-01-04
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidenceKLF7_HUMANKLF3_MOUSE3029077.7829.82002133022533424E-43171
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
KLF7_HUMANIPR013087GO:0003676DomainZinc finger C2H2-type/integrase DNA-binding domainMolecular Functionnucleic acid binding
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/O75840_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


MaxQB

Evidence File
/mnt/mpp/ms_data/O75840_maxqb.txt
Reference
Christoph Schaab, Tamar Geiger, Gabriele Stoehr, Juergen Cox and Matthias Mann: "Analysis of high-accuracy, quantitative proteomics data in the MaxQB database", Mol Cell Proteomics 11 (2012) M111.014068.
http://maxqb.biochem.mpg.de/mxdb/ ">MaxQB


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/O75840_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Proteomics DB

Evidence File
/mnt/mpp/ms_data/O75840_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB