NKX6-3:Homeobox protein Nkx-6.3

Gene Name
Homeobox protein Nkx-6.3
Protein ID
A6NJ46
Chromosome ID
8
HPP Status
2
Protein Name
Homeobox protein Nkx-6.3
Synonyms

NKX6.3

homeobox protein Nkx-6.3

NK6 transcription factor related, locus 3 (Drosophila)

NK6 homeobox 3

NK6 transcription factor related, locus 3


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=NKX6-3 ]
Chromosomal Position
8p11.21 | Start:41645178 End:41645178
Sequence
A6NJ46.fasta
Description

Entrez Gene Summary for NKX6-3
The NKX family of homeodomain proteins controls numerous developmental processes. Members of the NKX6 subfamily, including NKX6-3, are involved in development of the central nervous system (CNS), gastrointestinal tract, and pancreas (Alanentalo et al., 2006 (PubMed 16326147)).(supplied by OMIM, Mar 2008)

UniProtKB Summary for NKX6-3
Function: Putative transcription factor, which may be involved in patterning of central nervous system and pancreas (By similarity)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=NKX6-3 ]
External IDs
Hgnc ID: 26328 EntrezGene ID: 157848 Ensembl ID: ENSG00000165066
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=NKX6-3 ]
Reference Source
http://www.nextprot.org

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidenceNKX63_HUMANTLX1_MOUSE2656460.9424.152501382012022651E-1580
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
NKX63_HUMANIPR000047GO:0000976Conserved_siteHelix-turn-helix motifMolecular Functiontranscription regulatory region sequence-specific DNA binding
NKX63_HUMANIPR001356GO:0003700DomainHomeobox domainMolecular Functionsequence-specific DNA binding transcription factor activity
NKX63_HUMANIPR001356GO:0043565DomainHomeobox domainMolecular Functionsequence-specific DNA binding
NKX63_HUMANIPR009057GO:0003677DomainHomeodomain-likeMolecular FunctionDNA binding
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/A6NJ46_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


Proteomics DB

Evidence File
/mnt/mpp/ms_data/A6NJ46_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB