Gene Name
Protein ID
Chromosome ID
HPP Status
Protein Name


calpain 14


Calcium-activated neutral proteinase 14

calcium-activated neutral proteinase 14

EC 3.4.22.-

[Reference: ]
Chromosomal Position
2p23.1 | Start:31173056 End:31173056

Entrez Gene Summary for CAPN14
Calpains are a family of cytosolic calcium-activated cysteine proteases involved in a variety of cellular processes including apoptosis, cell division, modulation of integrin-cytoskeletal interactions, and synaptic plasticity (Dear et al., 2000 (PubMed 10964513)). CAPN14 belongs to the calpain large subunit family.(supplied by OMIM, Mar 2008)

UniProtKB Summary for CAPN14
Function: Calcium-regulated non-lysosomal thiol-protease (By similarity)

Tocris Summary for CAPN14
Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals. This family contains 14 members with mu-calpain (calpain 1) and m-calpain (calpain 2) being the most well-characterized. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure. Calpains are regulated by Ca2+ concentration, phosphorylation, calpastatin and probably by altering their subcellular localization (limiting access to substrate). These endopeptidases have numerous functions including, but not limited to, remodeling of cytoskeletal attachments to the plasma membrane during cell fusion and cell motility, proteolytic modification of molecules in signal transduction pathways, degradation of enzymes controlling progression through the cell cycle, regulation of gene expression, substrate degradation in some apoptotic pathways, and an involvement in long-term potentiation. Perturbations in calpain activity have been associated in pathophysiological processes contributing to type II diabetes (calpain 10), Alzheimer's disease (calpain 1), gastric cancer (calpain 9) and muscular dystrophy (calpain 3).

[Reference: ]
External IDs
Hgnc ID: 16664 EntrezGene ID: 440854 Ensembl ID: ENSG00000214711
[Reference: ]
Reference Source

Gene Reference Into Function (GeneRIF)

PubMed IDGeneRIF TextLast Update
25407941Eosinophilic esophagitis was associate with increased expression of CAPN14.2015-11-21


Relevant citations within the PubMed literature


Putative/known Functions


Homologues, Orthologues, Paralogues and Family

Sequence Similarity and Functional Annotation

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
CAN14_HUMANIPR001300GO:0004198DomainPeptidase C2, calpain, catalytic domainMolecular Functioncalcium-dependent cysteine-type endopeptidase activity
CAN14_HUMANIPR001300GO:0005622DomainPeptidase C2, calpain, catalytic domainCellular Componentintracellular
CAN14_HUMANIPR001300GO:0006508DomainPeptidase C2, calpain, catalytic domainBiological Processproteolysis
CAN14_HUMANIPR011992GO:0005509DomainEF-hand domain pairMolecular Functioncalcium ion binding
CAN14_HUMANIPR022684GO:0004198FamilyPeptidase C2, calpain familyMolecular Functioncalcium-dependent cysteine-type endopeptidase activity
CAN14_HUMANIPR022684GO:0005622FamilyPeptidase C2, calpain familyCellular Componentintracellular
CAN14_HUMANIPR022684GO:0006508FamilyPeptidase C2, calpain familyBiological Processproteolysis
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications

Protein Protein Interactions

Best Available Mass Spectra without FDR


Evidence File
Christoph Schaab, Tamar Geiger, Gabriele Stoehr, Juergen Cox and Matthias Mann: "Analysis of high-accuracy, quantitative proteomics data in the MaxQB database", Mol Cell Proteomics 11 (2012) M111.014068. ">MaxQB

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Proteomics DB

Evidence File
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7. ">Proteomics DB