CAPN14:Calpain-14
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Gene Name
Calpain-14 |
Protein ID
A8MX76 |
Chromosome ID
2 |
HPP Status
2 |
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Protein Name
Calpain-14 |
Synonyms
calpain-14 calpain 14 CANP 14 Calcium-activated neutral proteinase 14 calcium-activated neutral proteinase 14 EC 3.4.22.- [Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=CAPN14  ] |
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Chromosomal Position
2p23.1 | Start:31173056 End:31173056 |
Sequence
A8MX76.fasta |
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Description
Entrez Gene Summary for CAPN14Calpains are a family of cytosolic calcium-activated cysteine proteases involved in a variety of cellular processes including apoptosis, cell division, modulation of integrin-cytoskeletal interactions, and synaptic plasticity (Dear et al., 2000 (PubMed 10964513)). CAPN14 belongs to the calpain large subunit family.(supplied by OMIM, Mar 2008) UniProtKB Summary for CAPN14Function: Calcium-regulated non-lysosomal thiol-protease (By similarity) Tocris Summary for CAPN14 Calpains are a group of calcium-sensitive cysteine proteases that are ubiquitously expressed in mammals. This family contains 14 members with mu-calpain (calpain 1) and m-calpain (calpain 2) being the most well-characterized. Structurally, calpains contain two subunits; an 80 kDa catalytic subunit and a 28 kDa regulatory subunit that functions as a chaperone to stabilize the 80 kDa structure. Calpains are regulated by Ca2+ concentration, phosphorylation, calpastatin and probably by altering their subcellular localization (limiting access to substrate). These endopeptidases have numerous functions including, but not limited to, remodeling of cytoskeletal attachments to the plasma membrane during cell fusion and cell motility, proteolytic modification of molecules in signal transduction pathways, degradation of enzymes controlling progression through the cell cycle, regulation of gene expression, substrate degradation in some apoptotic pathways, and an involvement in long-term potentiation. Perturbations in calpain activity have been associated in pathophysiological processes contributing to type II diabetes (calpain 10), Alzheimer's disease (calpain 1), gastric cancer (calpain 9) and muscular dystrophy (calpain 3). [Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=CAPN14 ] |
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External IDs
Hgnc ID: 16664 EntrezGene ID: 440854 Ensembl ID: ENSG00000214711 [Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=CAPN14 ] |
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Reference Source
http://www.nextprot.org |
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Gene Reference Into Function (GeneRIF)
| PubMed ID | GeneRIF Text | Last Update |
|---|---|---|
| 25407941 | Eosinophilic esophagitis was associate with increased expression of CAPN14. | 2015-11-21 |
| Reference http://www.ncbi.nlm.nih.gov/gene/about-generif ftp://ftp.ncbi.nih.gov/gene/GeneRIF/ | ||
OMICSDI Browser
Relevant citations within the PubMed literature
Putative/known Functions
Localisation
Homologues, Orthologues, Paralogues and Family
Sequence Similarity and Functional Annotation
InterProScan Annotation
| Uniprot ID | Interpro ID | Go ID | Type | Name | Category | Description |
|---|---|---|---|---|---|---|
| CAN14_HUMAN | IPR001300 | GO:0004198 | Domain | Peptidase C2, calpain, catalytic domain | Molecular Function | calcium-dependent cysteine-type endopeptidase activity |
| CAN14_HUMAN | IPR001300 | GO:0005622 | Domain | Peptidase C2, calpain, catalytic domain | Cellular Component | intracellular |
| CAN14_HUMAN | IPR001300 | GO:0006508 | Domain | Peptidase C2, calpain, catalytic domain | Biological Process | proteolysis |
| CAN14_HUMAN | IPR011992 | GO:0005509 | Domain | EF-hand domain pair | Molecular Function | calcium ion binding |
| CAN14_HUMAN | IPR022684 | GO:0004198 | Family | Peptidase C2, calpain family | Molecular Function | calcium-dependent cysteine-type endopeptidase activity |
| CAN14_HUMAN | IPR022684 | GO:0005622 | Family | Peptidase C2, calpain family | Cellular Component | intracellular |
| CAN14_HUMAN | IPR022684 | GO:0006508 | Family | Peptidase C2, calpain family | Biological Process | proteolysis |
| Reference Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83. | ||||||