TDH:Inactive L-threonine 3-dehydrogenase, mitochondrial

Gene Name
Inactive L-threonine 3-dehydrogenase, mitochondrial
Protein ID
Q8IZJ6
Chromosome ID
8
HPP Status
2
Protein Name
Inactive L-threonine 3-dehydrogenase, mitochondrial
Synonyms

"short chain dehydrogenase/reductase family 14E

L-threonine dehydrogenase (pseudogene)

SDR14E1P

member 1 (pseudogene)"

L-threonine dehydrogenase


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=TDH ]
Chromosomal Position
8p23.1 | Start:11339637 End:11339637
Sequence
Q8IZJ6.fasta
Description

Entrez Gene Summary for TDH
This gene appears to be an evolving pseudogene of L-threonine 3-dehydrogenase (TDH). In both prokaryotes and eukaryotes, TDH catalyzes the first of two steps in one of two L-threonine degradation pathways. However, in human, the single gene with sequence similarity to TDH is not capable of encoding a functional TDH protein; the predicted protein lacks most of the C-terminus and parts of the NAD+ binding motif when compared to other species' TDH proteins. This suggests that the human gene is therefore a pseudogene. Transcripts of this gene are found in all tissues and alternatively spliced transcripts have been described. It is not known if these transcripts are translated, or if the possible protein product provides any functional role. (provided by RefSeq, Jul 2008)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=TDH ]
External IDs
Hgnc ID: 15547 EntrezGene ID: 157739 Ensembl ID: ENSG00000154316
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=TDH ]
Reference Source
http://www.nextprot.org

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidenceTDH_HUMANTDH_PIG23021581.493.48361121112151E-93338
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
TDH_HUMANIPR001509GO:0003824DomainNAD-dependent epimerase/dehydrataseMolecular Functioncatalytic activity
TDH_HUMANIPR001509GO:0044237DomainNAD-dependent epimerase/dehydrataseBiological Processcellular metabolic process
TDH_HUMANIPR001509GO:0050662DomainNAD-dependent epimerase/dehydrataseMolecular Functioncoenzyme binding
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/Q8IZJ6_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Proteomics DB

Evidence File
/mnt/mpp/ms_data/Q8IZJ6_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB