CAMK2N2:Calcium/calmodulin-dependent protein kinase II inhibitor 2

Gene Name
Calcium/calmodulin-dependent protein kinase II inhibitor 2
Protein ID
Q96S95
Chromosome ID
3
HPP Status
2
Protein Name
Calcium/calmodulin-dependent protein kinase II inhibitor 2
Synonyms

CAM-KIIN

CaM-KII inhibitory protein

CaM-KIIN

CAMKIIN

calcium/calmodulin-dependent protein kinase II inhibitor 2


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=CAMK2N2 ]
Chromosomal Position
3q27.1 | Start:184259213 End:184259213
Sequence
Q96S95.fasta
Description

Entrez Gene Summary for CAMK2N2
This gene encodes a protein that is highly similar to the rat CaM-KII inhibitory protein, an inhibitor of calcium/calmodulin-dependent protein kinase II (CAMKII). CAMKII regulates numerous physiological functions, including neuronal synaptic plasticity through the phosphorylation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate (AMPA) receptors. Studies of the similar protein in rat suggest that this protein may function as a negative regulator of CaM-KII and may act to inhibit the phosphorylation of AMPA receptors. (provided by RefSeq, Jul 2008)

UniProtKB Summary for CAMK2N2
Function: Potent and specific cellular inhibitor of CaM-kinase II (CAMK2). Traps Ca(2+)/calmodulin on CAMK2. May play an important role in the regulation of cell growth when overexpressed in colon adenocarcinoma LoVo cells. Traps Ca(2+)/calmodulin on CAMK2

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=CAMK2N2 ]
External IDs
Hgnc ID: 24197 EntrezGene ID: 94032 Ensembl ID: ENSG00000163888
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=CAMK2N2 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
9724800Functional study of the rat homolog2003-04-02
19586909hCaMKIINbeta may play an important role in the regulation of tumor cell growth2010-01-21
20487031We show that CaMKII N beta expression is differentially regulated by novelty and contextual fear conditioning, providing further insight into molecular basis of fear LTM.2011-01-01
23153928Murine double minute 2 (MDM2) protein levels were decreased in AD cells relative to control lymphoblasts, suggesting an impairment of FOXO3a degradation.2013-08-03
23545117Mutant FUS-DeltaNLS increased calcium/calmodulin-dependent protein kinase II inhibitor 2 (CAMK2N2) at both mRNA and protein levels.2013-09-21
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidenceCK2N2_HUMANCK2N2_RAT797998.73100101791794E-32131
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
CK2N2_HUMANIPR026779GO:0004860FamilyCalcium/calmodulin-dependent protein kinase II inhibitorMolecular Functionprotein kinase inhibitor activity
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




Showing 1-10 of 10 items.

gpmDB

Peptide SequenceEvidence LevelLog ENumber Of ObservationSpectraAccession IDProteotypicityAnnotation
FGADPEGSDLSFSCRgreen-15.0911ENSP00000296238Proteotypic
FGADPEGSDLSFSCRgreen-15.0911ENSP00000296238Proteotypic
FGADPEGSDLSFSCRgreen-13.5911ENSP00000296238Proteotypic
FGADPEGSDLSFSCRgreen-13.5911ENSP00000296238Proteotypic
LQDTNSFFAGNQAKgreen-10.0771ENSP00000296238Proteotypic
LQDTNSFFAGNQAKgreen-10.0771ENSP00000296238Proteotypic
LQDTNSFFAGNQAKgreen-9.7771ENSP00000296238Proteotypic
LQDTNSFFAGNQAKgreen-9.7771ENSP00000296238Proteotypic
LQDTNSFFAGNQAKgreen-6.5771ENSP00000296238Proteotypic
LQDTNSFFAGNQAKgreen-6.5771ENSP00000296238Proteotypic
Evidence File
/mnt/mpp/ms_data/Q96S95_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


Proteomics DB

Evidence File
/mnt/mpp/ms_data/Q96S95_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB