SPAG11A:Sperm-associated antigen 11A

Gene Name
Sperm-associated antigen 11A
Protein ID
Q6PDA7
Chromosome ID
8
HPP Status
2
Protein Name
Sperm-associated antigen 11A
Synonyms

EDDM2A

HE2

Human epididymis-specific protein 2

He2

EP2

Protein EP2

sperm-associated antigen 11A

epididymal protein 2A

human epididymis-specific protein 2

"epididymal protein 2A"

sperm associated antigen 11A

sperm antigen HE2

Sperm antigen HE2


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=SPAG11A ]
Chromosomal Position
8p23.1 | Start:7847876 End:7847876
Sequence
Q6PDA7.fasta
Description

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=SPAG11A ]
External IDs
Hgnc ID: 33342 EntrezGene ID: 653423 Ensembl ID: ENSG00000178287
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=SPAG11A ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
10819450In the chimpanzee epididymis, several mRNA HE2/EP2 variants are produced. Of these, three cDNAs code for two different protein sequences that have a cysteine distribution characteristic for beta-defensins.2001-04-26
11259252The human HE2/EP2 gene is the fusion product of two ancestral beta-defensin genes. During its evolution, the gene has acquired additional exons whose inclusion produces new message variants that encode peptides unrelated to defensins.2001-04-26
12193388HE2 peptides were detected in human epididymal epithelium, epididymal fluid, and ejaculate2010-01-21
14662784HE2 transcriptional and translational products normally expressed in the caput epididymidis were not affected by vasectomy.2010-01-21
15229135EP2 expression is more widespread in male reproductive tract than realized previously. Activity of every EP2 variant tested is antibacterial. Further investigation may reveal additional roles for EP2 peptides in primate male reproductive tract.2010-01-21
16411022Isoform C of SPAG11B encodes a peptide with antimicrobial activity against E. coli.2014-11-19
19535787SPAG11B/D is both a substrate and a potent inhibitor of TPSAB1 activity.2010-01-21
21933954Combination of two proteins, SPAG11B and TEX101, can be used for differential diagnosis of azoospermia2012-04-07
25573789we report the three dimensional structure of the human SPAG11B proteins and their C-terminal peptides. web-based hydropathy, amphipathicity, and topology (WHAT) analyses and grand average of hydropathy2015-12-12
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalianSG11A_HUMANSPG11_PANTR12310310083.7400110311033E-55210
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
SG11A_HUMANIPR007988GO:0005576FamilySperm antigen HE2Cellular Componentextracellular region
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/Q6PDA7_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Proteomics DB

Evidence File
/mnt/mpp/ms_data/Q6PDA7_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB