ASB14:Ankyrin repeat and SOCS box protein 14

Gene Name
Ankyrin repeat and SOCS box protein 14
Protein ID
A6NK59
Chromosome ID
3
HPP Status
2
Protein Name
Ankyrin repeat and SOCS box protein 14
Synonyms

ankyrin repeat and SOCS box containing 14

ankyrin repeat domain-containing SOCS box protein Asb-14

ankyrin repeat and SOCS box-containing 14

ankyrin repeat and SOCS box protein 14

ASB-14


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ASB14 ]
Chromosomal Position
3p14.3 | Start:57268347 End:57268347
Sequence
A6NK59.fasta
Description

Entrez Gene Summary for ASB14
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternative splicing results in multiple transcript variants encoding different isoforms.(provided by RefSeq, Dec 2008)

UniProtKB Summary for ASB14
Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ASB14 ]
External IDs
Hgnc ID: 19766 EntrezGene ID: 142686 Ensembl ID: ENSG00000239388
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=ASB14 ]
Reference Source
http://www.nextprot.org

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
ASB14_HUMANIPR001496GO:0035556DomainSOCS protein, C-terminalBiological Processintracellular signal transduction
ASB14_HUMANIPR002110GO:0005515RepeatAnkyrin repeatMolecular Functionprotein binding
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




Proteomics DB

Evidence File
/mnt/mpp/ms_data/A6NK59_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB