ASB14:Ankyrin repeat and SOCS box protein 14

Gene Name
Ankyrin repeat and SOCS box protein 14
Protein ID
Chromosome ID
HPP Status
Protein Name
Ankyrin repeat and SOCS box protein 14

ankyrin repeat and SOCS box containing 14

ankyrin repeat domain-containing SOCS box protein Asb-14

ankyrin repeat and SOCS box-containing 14

ankyrin repeat and SOCS box protein 14


[Reference: ]
Chromosomal Position
3p14.3 | Start:57268347 End:57268347

Entrez Gene Summary for ASB14
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternative splicing results in multiple transcript variants encoding different isoforms.(provided by RefSeq, Dec 2008)

UniProtKB Summary for ASB14
Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity)

[Reference: ]
External IDs
Hgnc ID: 19766 EntrezGene ID: 142686 Ensembl ID: ENSG00000239388
[Reference: ]
Reference Source


Relevant citations within the PubMed literature


Putative/known Functions


Homologues, Orthologues, Paralogues and Family

Sequence Similarity and Functional Annotation

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
ASB14_HUMANIPR001496GO:0035556DomainSOCS protein, C-terminalBiological Processintracellular signal transduction
ASB14_HUMANIPR002110GO:0005515RepeatAnkyrin repeatMolecular Functionprotein binding
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications

Protein Protein Interactions

Best Available Mass Spectra without FDR

Proteomics DB

Evidence File
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7. ">Proteomics DB