HTR1F:5-hydroxytryptamine receptor 1F

Gene Name
5-hydroxytryptamine receptor 1F
Protein ID
P30939
Chromosome ID
3
HPP Status
2
Protein Name
5-hydroxytryptamine receptor 1F
Synonyms

5-HT-1F

serotonin receptor 1F

MR77

Serotonin receptor 1F

5-HT1F

5HT6

5-hydroxytryptamine (serotonin) receptor 1F

5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled

5-hydroxytryptamine receptor 1F

HTR1EL


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=HTR1F ]
Chromosomal Position
3p11.1 | Start:87990696 End:87990696
Sequence
P30939.fasta
Description

UniProtKB Summary for HTR1F
Function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity

Tocris Summary for HTR1F
Serotonin 5-HT1F receptors, previously known as 5-HT1Ebeta receptors, are located primarily in the hippocampus, cortex and dorsal raphe nucleus. The physiological role of 5-HT1F receptors is currently unknown. The human 5-HT1F receptor gene has been localized to chromosome 3 (3q11).

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=HTR1F ]
External IDs
Hgnc ID: 5292 EntrezGene ID: 3355 Ensembl ID: ENSG00000179097
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=HTR1F ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
12627464Observational study of gene-disease association. (HuGE Navigator)2008-03-13
16856120Observational study of gene-disease association. (HuGE Navigator)2008-03-13
19086053Observational study of gene-disease association. (HuGE Navigator)2009-01-11
19156168Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)2009-02-11
19455600Observational study of gene-disease association. (HuGE Navigator)2009-06-24
214570695-HT6 show no striking effects on executive function in the Chinese Han population.2011-09-10
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidence5HT1F_HUMAN5HT1E_CAVPO36634659.5494.54132423365223623E-103371
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
5HT1F_HUMANIPR000276GO:0004930FamilyG protein-coupled receptor, rhodopsin-likeMolecular FunctionG-protein coupled receptor activity
5HT1F_HUMANIPR000276GO:0007186FamilyG protein-coupled receptor, rhodopsin-likeBiological ProcessG-protein coupled receptor signaling pathway
5HT1F_HUMANIPR000276GO:0016021FamilyG protein-coupled receptor, rhodopsin-likeCellular Componentintegral to membrane
5HT1F_HUMANIPR000450GO:0004993Family5-Hydroxytryptamine 1F receptorMolecular Functionserotonin receptor activity
5HT1F_HUMANIPR000450GO:0005887Family5-Hydroxytryptamine 1F receptorCellular Componentintegral to plasma membrane
5HT1F_HUMANIPR000450GO:0007186Family5-Hydroxytryptamine 1F receptorBiological ProcessG-protein coupled receptor signaling pathway
5HT1F_HUMANIPR002231GO:0004993Family5-hydroxytryptamine receptor familyMolecular Functionserotonin receptor activity
5HT1F_HUMANIPR002231GO:0005887Family5-hydroxytryptamine receptor familyCellular Componentintegral to plasma membrane
5HT1F_HUMANIPR002231GO:0007186Family5-hydroxytryptamine receptor familyBiological ProcessG-protein coupled receptor signaling pathway
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

KEGG Pathways

Pathway IDDatabase NamePathway Name
hsa04080KEGG PATHWAYNeuroactive ligand-receptor interaction
hsa04726KEGG PATHWAYSerotonergic synapse
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/P30939_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


Proteomics DB

Evidence File
/mnt/mpp/ms_data/P30939_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB