SSPO:SCO-spondin

Gene Name
SCO-spondin
Protein ID
A2VEC9
Chromosome ID
7
HPP Status
2
Protein Name
SCO-spondin
Synonyms

SCO-spondin

"subcommissural organ spondin"

KIAA2036

thrombospondin domain containing"

"SCO protein

SCO protein, thrombospondin domain containing

subcommissural organ spondin

SCO-spondin homolog (Bos taurus)


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=SSPO ]
Chromosomal Position
7q36.1 | Start:149776042 End:149776042
Sequence
A2VEC9.fasta
Description

UniProtKB Summary for SSPO
Function: Involved in the modulation of neuronal aggregation. May be involved in developmental events during the formation of the central nervous system (By similarity)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=SSPO ]
External IDs
Hgnc ID: 21998 EntrezGene ID: 23145 Ensembl ID: ENSG00000197558
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=SSPO ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
15053980demonstrated SCO-spondin expression at relevant steps of gestation in the placenta2010-01-21
19913121Observational study of gene-disease association. (HuGE Navigator)2010-09-15
20628086Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)2010-09-15
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions


Biological function

Function Description

Cell adhesion

Reference
http://www.uniprot.org/uniprot/A2VEC9
Contributed By
Chromosome 7 Research Group Australia

Molecular function

Function Description

peptidase inhibitor activity

Reference
http://www.uniprot.org/uniprot/A2VEC9
Contributed By
Chromosome 7 Research Group Australia

Primary

Function Description

Involved in the modulation of neuronal aggregation. May be involved in developmental events during the formation of the central nervous system.

Reference
http://www.uniprot.org/uniprot/A2VEC9
Contributed By
Chromosome 7 Research Group Australia

Localisation


Subcellular

Localization Description

Secreted, extracellular space

Reference
http://www.uniprot.org/uniprot/A2VEC9#subcellular_location
Contributed By
Chromosome 7 Research Group Australia

Tissue

Localization Description

This gene is overexpressed in colon, platelet, and stomach.

Reference
http://www.genecards.org/cgi-bin/carddisp.pl?gene=SSPO&keywords=A2VEC9#protein_expression
Contributed By
Chromosome 7 Research Group Australia

Homologues, Orthologues, Paralogues and Family


Orthologues

Orthologs

cow (Bos Taurus), dog (Canis familiaris), mouse(Mus musculus), chimpanzee(Pan troglodytes), rat (Rattus norvegicus), chicken(Gallus gallus), tropical clawed frog (Silurana tropicalis), zebrafish(Danio rerio)

Reference
http://www.genecards.org/cgi-bin/carddisp.pl?gene=SSPO&keywords=A2VEC9#protein_expression
Contributed By
Chromosome 7 Research Group Australia

Paralogues

Paralogs

OTOG, MUC6, OTOGL, FCGBP, MUC5AC, ZAN, TECTA, VWF, MUC5B

Reference
http://www.genecards.org/cgi-bin/carddisp.pl?gene=SSPO&keywords=A2VEC9#protein_expression
Contributed By
Chromosome 7 Research Group Australia

Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidenceSSPO_HUMANATS1_MOUSE51475851.721.13280325333105616183E-1170
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
SSPO_HUMANIPR000421GO:0007155DomainCoagulation factor 5/8 C-terminal type domainBiological Processcell adhesion
SSPO_HUMANIPR001007GO:0005515Domainvon Willebrand factor, type CMolecular Functionprotein binding
SSPO_HUMANIPR002172GO:0005515RepeatLow-density lipoprotein (LDL) receptor class A repeatMolecular Functionprotein binding
SSPO_HUMANIPR008037GO:0030414RepeatProteinase inhibitor I19, pacifastinMolecular Functionpeptidase inhibitor activity
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications


Showing 1-6 of 6 items.

Post Translational Modifications

Ptm NamePtm SiteEvidence
GlycosylationAsn 88, Asn 130, Asn 261, Asn 514, Asn 819, Asn 911, Asn 944, Asn 986, Asn 1352, Asn 1650, Asn 1663, Asn 1809, Asn 1993, Asn 2030, Asn 2133, Asn 2645, Asn 2694, Asn 2936, Asn 2967, Asn 3062, Asn 3116, Asn 3163, Asn 3173, Asn 3310, Asn 3399, Asn 3512, Asn 3522, Asn 3599, Asn 3626, Asn 3792, Asn 3914, Asn 3946, Asn 4139, Asn 4346, Asn 4417, Asn 4731, Asn 4748, Asn 4753, Asn 4863, Asn 4903, Asn 4948, Asn 4955, and Asn 5061 <p>match to sequence model evidence used in manual assertion</p>
PhosphorylationY533 - p<p>Mass spectrometry of lung cancer, non-small cell lung adenocarcinoma tissue</p><p>Relevant cell line - cell type - tissue: PC9-TAR (pulmonary) </p>
PhosphorylationT1075 - p, S2435 - p, S3068 - p, T3076 - p<p>mass spectrometry of Jurkat (T lymphocyte) cells</p>
PhosphorylationS2420 - p<p>-</p>
PhosphorylationT3766 - p, S3782 - p, T3785 - p <p>Mass spectrometry of leukocyte blood cells</p>
PhosphorylationT3842 - p<p>Mass spectrometry</p>

Protein Protein Interactions


Database Name

BioGRID

Database Link

http://thebiogrid.org/116762 ">http://thebiogrid.org/116762

Interaction

Physical association between interacting partners

Interacting Partner

ATN1 (High throughput), ATXN7L1 ( low throughput), TTC28 (low throughput)

Reference
http://thebiogrid.org/116762
Contributed By
Chromosome 7 Research Group Australia

Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/A2VEC9_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


MaxQB

Evidence File
/mnt/mpp/ms_data/A2VEC9_maxqb.txt
Reference
Christoph Schaab, Tamar Geiger, Gabriele Stoehr, Juergen Cox and Matthias Mann: "Analysis of high-accuracy, quantitative proteomics data in the MaxQB database", Mol Cell Proteomics 11 (2012) M111.014068.
http://maxqb.biochem.mpg.de/mxdb/ ">MaxQB


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/A2VEC9_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Showing 1-2 of 2 items.

Proteomics DB

Peptide SequenceSearch EngineScoreThreshold ScoreIdentification IDExperiment IDAnnotation
MLLPALLFGMAWALADGRMascot3.763269937431122
SRSCSSPPSKMaxquant125.74058476182101
Evidence File
/mnt/mpp/ms_data/A2VEC9_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB