HTR5A:5-hydroxytryptamine receptor 5A

Gene Name
5-hydroxytryptamine receptor 5A
Protein ID
Chromosome ID
HPP Status
Protein Name
5-hydroxytryptamine receptor 5A

serotonin receptor 5A



5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled

5-hydroxytryptamine receptor 5A

5-hydroxytryptamine (serotonin) receptor 5A

Serotonin receptor 5A


[Reference: ]
Chromosomal Position
7q36.2 | Start:155070324 End:155070324

Entrez Gene Summary for HTR5A
The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of 5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G-proteins. This protein has been shown to function in part through the regulation of intracellular Ca2+ mobilization. (provided by RefSeq, Jul 2008)

UniProtKB Summary for HTR5A
Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins

Tocris Summary for HTR5A
Serotonin 5-ht5 receptors are G-protein-coupled receptors that preferentially couple to Gs and promote cAMP formation. Two 5-ht5 receptor subtypes (5-ht5A and 5-ht5B) sharing 70% overall sequence identity have been found in rodents, but a functional transcript of the 5-ht5A receptor has not been identified in humans

[Reference: ]
External IDs
Hgnc ID: 5300 EntrezGene ID: 3361 Ensembl ID: ENSG00000157219
[Reference: ]
Reference Source

Gene Reference Into Function (GeneRIF)

PubMed IDGeneRIF TextLast Update
7988681The receptor has been transiently expressed in Cos M6 cells and exhibits a pharmacological profile closely resembling the mouse and rat 5-HT5A receptors with high, specific binding for ergotamine and methiothepin.2005-11-10
11317225Observational study of gene-disease association. (HuGE Navigator)2008-03-13
12627464Observational study of gene-disease association. (HuGE Navigator)2008-03-13
15581469Meta-analysis of gene-disease association. (HuGE Navigator)2008-03-13
16701945Observational study of gene-disease association. (HuGE Navigator)2008-03-13
17203304Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)2008-03-13
17881091N-glycosylation of the N6 residue is important for the membrane expression of this 5-HT5A neurotransmitter receptor; a requirement for receptor function.2010-01-21
18079067Observational study of gene-disease association. (HuGE Navigator)2008-03-13
18253134Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator)2008-04-03
18802937In individuals in Brazil with the A/A variant of the -1438G/A polymorphism of the 2A receptor gene, the effect of cultural consonance in family life on depressive symptoms over a 2 year period was larger than those with the G/A or G/G variants.2010-01-21
19086053Observational study of gene-disease association. (HuGE Navigator)2009-01-11
19156168Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)2009-02-11
19328558Association of a SNP of HTR5A gene is a susceptibility factor to bipolar disease in Bulgarian population.2010-02-22
19328558Observational study of gene-disease association. (HuGE Navigator)2009-04-08
19381154Childhood anxiousness did not mediate the effects of HTR2A and HTR5A on mood disorders.2010-12-04
19381154Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)2009-04-29
19455600Observational study of gene-disease association. (HuGE Navigator)2009-06-24
20388841Observational study of gene-disease association. (HuGE Navigator)2010-06-30
20388841Serotonin (5-HT) receptor 5A sequence variants affect human plasma triglyceride levels2010-10-30
20468064Observational study of gene-disease association. (HuGE Navigator)2010-06-30
20734064Observational study of gene-disease association. (HuGE Navigator)2010-12-05
24903772Results suggest that TPH1 218A/C and HTR5A 12A/T polymorphisms cannot predict treatment response in major depression2015-02-28


Relevant citations within the PubMed literature


Putative/known Functions

Cellular function



Homologues, Orthologues, Paralogues and Family




Sequence Similarity and Functional Annotation

Post Translational Modifications

Showing 1-1 of 1 item.

Post Translational Modifications

Ptm NamePtm SiteEvidence
PhosphorylationT260?p Y345?p S347?p S354?p<p>KQPQMVFtVRHATVT</p><p>YTAFNKNyNsAFKNF</p><p>AFNKNyNsAFKNFFs</p><p>sAFKNFFsRQH____</p>

Protein Protein Interactions

Best Available Mass Spectra without FDR


Evidence File
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803. ">Global Proteome Machine Database - THE GPM


Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456. ">PRIDE Archive

Proteomics DB

Evidence File
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7. ">Proteomics DB

Structural Studies

Disease Databases

Drug Studies