FBXO8:F-box only protein 8

Gene Name
F-box only protein 8
Protein ID
Q9NRD0
Chromosome ID
4
HPP Status
2
Protein Name
F-box only protein 8
Synonyms

F-box/SEC7 protein FBS

F-box only protein 8

FBX8

F-box protein Fbx8

FBS

F-box protein 8


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=FBXO8 ]
Chromosomal Position
4q34.1 | Start:174236658 End:174236658
Sequence
Q9NRD0.fasta
Description

Entrez Gene Summary for FBXO8
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It contains a C-terminal amino acid sequence that bears a significant similarity with a portion of yeast Sec7p, a critical regulator of vesicular protein transport. This human protein may interact with ADP-ribosylation factor(s)(ARFs) and exhibit ARF-GEF (guanine nucleotide exchange factor) activity. (provided by RefSeq, Jul 2008)

UniProtKB Summary for FBXO8
Function: May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=FBXO8 ]
External IDs
Hgnc ID: 13587 EntrezGene ID: 26269 Ensembl ID: ENSG00000164117
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=FBXO8 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
18987618Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)2008-11-19
20848231FBX8 is a novel c-Myc binding protein and that c-Myc induces cell invasive activity2011-02-26
25550853FBX8 down-expression was an independent prognostic indicator for glioma patient's survival.2015-09-12
25801334FBX8 was markedly down-regulated in gastric cancer tissues. Knocking down FBX8 promoted proliferation and invasion in tumor cell line. Patients with low FBX8 had poor prognosis.2015-08-01
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation



Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/Q9NRD0_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


Proteomics DB

Evidence File
/mnt/mpp/ms_data/Q9NRD0_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB