SLC9B1:Sodium/hydrogen exchanger 9B1

Gene Name
Sodium/hydrogen exchanger 9B1
Protein ID
Q4ZJI4
Chromosome ID
4
HPP Status
1
Protein Name
Sodium/hydrogen exchanger 9B1
Synonyms

Sodium/hydrogen exchanger-like domain-containing protein 1

Solute carrier family 9 subfamily B member 1

Na+/H+ exchanger domain containing 1

Na(+)/H(+) exchanger-like domain-containing protein 1

solute carrier family 9, subfamily B (cation proton antiporter 2), member 1

sodium/hydrogen exchanger-like domain-containing protein 1

NHE domain-containing protein 1

solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1

NHEDC1

NHA1

sodium/hydrogen exchanger 9B1


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC9B1 ]
Chromosomal Position
4q24 | Start:102885048 End:102885048
Sequence
Q4ZJI4.fasta
Description

Entrez Gene Summary for SLC9B1
The protein encoded by this gene is a sodium/hydrogen exchanger and transmembrane protein. Highly conserved orthologs of this gene have been found in other mammalian species. The expression of this gene may be limited to testis. Multiple transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2010)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC9B1 ]
External IDs
Hgnc ID: 24244 EntrezGene ID: 150159 Ensembl ID: ENSG00000164037
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC9B1 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
16850186cloning and characterization of a novel NHEDC1 (Na+/H+ exchanger like domain containing 1) gene; it was mapped to chromosome 4p24; molecular weight of NHEDC1 is about 56 KDa; it is exclusively expressed in the testis2010-01-21
25701605Results identified multiple cis-acting DNA regulatory elements in the 5 end of the SLC9B1 gene and shown that DNA methylation at these elements could provide mechanisms by which SLC9B1 expression is restricted to male germ cells.2015-05-30
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalianSL9B1_HUMANSL9B1_MACFA51551191.9899.22410151115110.00E+00911
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
SL9B1_HUMANIPR006153GO:0006812DomainCation/H+ exchangerBiological Processcation transport
SL9B1_HUMANIPR006153GO:0015299DomainCation/H+ exchangerMolecular Functionsolute:hydrogen antiporter activity
SL9B1_HUMANIPR006153GO:0016021DomainCation/H+ exchangerCellular Componentintegral to membrane
SL9B1_HUMANIPR006153GO:0055085DomainCation/H+ exchangerBiological Processtransmembrane transport
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/Q4ZJI4_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


Proteomics DB

Evidence File
/mnt/mpp/ms_data/Q4ZJI4_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB