RASA4:Ras GTPase-activating protein 4

Gene Name
Ras GTPase-activating protein 4
Protein ID
Chromosome ID
HPP Status
Protein Name
Ras GTPase-activating protein 4

Ca2+-promoted Ras inactivator


Calcium-promoted Ras inactivator

rasGAP-activating-like protein 2

Ras p21 protein activator 4



calcium-promoted Ras inactivator

ras GTPase-activating protein 4

RasGAP-activating-like protein 2

RAS p21 protein activator 4

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=RASA4 ]
Chromosomal Position
7q22.1 | Start:102573807 End:102573807

Entrez Gene Summary for RASA4
This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB Summary for RASA4
Function: Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=RASA4 ]
External IDs
Hgnc ID: 23181 EntrezGene ID: 10156 Ensembl ID: ENSG00000105808
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=RASA4 ]
Reference Source

Gene Reference Into Function (GeneRIF)

PubMed IDGeneRIF TextLast Update
11448776CAPRI (Ca2+-promoted Ras inactivator) a Ca2+-dependent Ras GTPase-activating protein (Ras GAP). Switches off the Ras-MAPK pathway following G protein-coupled receptor stimulated intracellular Ca2+ elevation that recruits CAPRI to the plasma membrane.2001-09-25
16009725CAPRI seems to low-pass filter the Ca2+ signal, converting different intensities of stimulation into different durations of Ras activity.2010-01-21
21460216Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities2011-08-06
25147919RASA4 isoform 2 promoter methylation correlated with clinical parameters predicting poor prognosis (older age, elevated fetal hemoglobin), with higher risk of relapse after hematopoietic stem cell transplantation, and with PTPN11 mutation.2015-05-16


Relevant citations within the PubMed literature


Putative/known Functions


Homologues, Orthologues, Paralogues and Family

Sequence Similarity and Functional Annotation

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
RASL2_HUMANIPR000008GO:0005515DomainC2 calcium-dependent membrane targetingMolecular Functionprotein binding
RASL2_HUMANIPR001562GO:0035556Conserved_siteZinc finger, Btk motifBiological Processintracellular signal transduction
RASL2_HUMANIPR001849GO:0005515DomainPleckstrin homology domainMolecular Functionprotein binding
RASL2_HUMANIPR001849GO:0005543DomainPleckstrin homology domainMolecular Functionphospholipid binding
RASL2_HUMANIPR001936GO:0005096DomainRas GTPase-activating proteinMolecular FunctionGTPase activator activity
RASL2_HUMANIPR001936GO:0005622DomainRas GTPase-activating proteinCellular Componentintracellular
RASL2_HUMANIPR001936GO:0051056DomainRas GTPase-activating proteinBiological Processregulation of small GTPase mediated signal transduction
RASL2_HUMANIPR008936GO:0005622DomainRho GTPase activation proteinCellular Componentintracellular
RASL2_HUMANIPR008936GO:0007165DomainRho GTPase activation proteinBiological Processsignal transduction
RASL2_HUMANIPR008973GO:0005515DomainC2 calcium/lipid-binding domain, CaLBMolecular Functionprotein binding
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications

Protein Protein Interactions

Best Available Mass Spectra without FDR


Evidence File
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM

Showing 1-1 of 1 item.


Peptide SequenceSearch EngineBest ScoreBest Evidence IDBest Raw File IDBest Msms ScanAnnotation
Evidence File
Christoph Schaab, Tamar Geiger, Gabriele Stoehr, Juergen Cox and Matthias Mann: "Analysis of high-accuracy, quantitative proteomics data in the MaxQB database", Mol Cell Proteomics 11 (2012) M111.014068.
http://maxqb.biochem.mpg.de/mxdb/ ">MaxQB


Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive

Showing 1-1 of 1 item.

Proteomics DB

Evidence File
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB