NPY5R:Neuropeptide Y receptor type 5

Gene Name
Neuropeptide Y receptor type 5
Protein ID
Q15761
Chromosome ID
4
HPP Status
2
Protein Name
Neuropeptide Y receptor type 5
Synonyms

NPYY5-R

NPYR5

Y5 receptor

neuropeptide Y receptor Y5

NPY-Y5 receptor

neuropeptide Y receptor type 5

NPY5-R


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=NPY5R ]
Chromosomal Position
4q32.2 | Start:163343939 End:163343939
Sequence
Q15761.fasta
Description

UniProtKB Summary for NPY5R
Function: Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders

Tocris Summary for NPY5R
Neuropeptide Y (NPY) receptors are a family of Gi/o-protein-coupled receptors that are currently divided into four subtypes: Y1, Y2, Y4 and Y5. NPY receptors mediate a diverse range of biological actions including stimulation of food intake, anxiolysis, modulation of circadian rhythm, pain transmission and control of pituitary hormone release. All four NPY receptor subtypes are found at high concentrations in the brain and colon and are also found in a wide variety of peripheral tissues at lower levels. The human genes encoding Y1, Y2 and Y5 receptors are located on chromosome 4q31.3-q32 and the human gene encoding Y4 is located on chromosome 10q11.2.

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=NPY5R ]
External IDs
Hgnc ID: 7958 EntrezGene ID: 4889 Ensembl ID: ENSG00000164129
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=NPY5R ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
12220433Observational study of gene-disease association. (HuGE Navigator)2008-03-13
12398768The authenticity of this transcript was confirmed by isolating part of its 5'UTR and analysing its tissue distribution,, we have shown that the two AUG triplets contained in the 5' untranslated region of Y5(L) mRNA did not affect receptor expression2010-01-21
15302312Observational study of gene-disease association. (HuGE Navigator)2008-03-13
15601626Functional studies of new ligands for this receptor.2010-01-21
16891622Neuropeptide-Y induced endothelial cell migration was mimicked by agonists and fully blocked by antagonists for any specific NPY receptor (NPY5R).2010-01-21
17325259Observational study of gene-disease association. (HuGE Navigator)2008-03-13
17426313Observational study of gene-disease association. (HuGE Navigator)2008-03-13
17426313single nucleotide polymorphisms in the NPY5R gene may have a role in dyslipidemia (elevated triglyceride concentrations and reduced high-density lipoprotein levels) in Mexican Americans2010-01-21
17948870Observational study of gene-disease association. (HuGE Navigator)2008-03-13
18828811Observational study of gene-disease association. (HuGE Navigator)2008-10-19
18828811Sequence variations in neuropeptide Y receptor genes (NPY5R and NPY2R) are associated with alcohol dependence, cocaine dependence, and comorbid alcohol and cocaine dependence.2010-01-21
19058789Observational study of gene-disease association. (HuGE Navigator)2009-01-11
19077438Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)2009-01-11
19086053Observational study of gene-disease association. (HuGE Navigator)2009-01-11
19481128Results suggest that rabbit and human Y1, Y2 and Y5 receptor subtypes are well conserved, whereas Y4 receptors are less well conserved.2010-01-21
19593212Observational study of gene-disease association. (HuGE Navigator)2009-08-12
19759915NPY1R and NPY5R have roles in nutrient-specific food intake in Europeans2010-02-08
19759915Observational study of gene-disease association. (HuGE Navigator)2009-12-02
19874574Observational study of gene-disease association. (HuGE Navigator)2009-12-02
20332211Together, our results suggest that Y5R plays an important role in cancer cell growth and migration and could be a novel therapeutic target for breast cancer.2010-07-19
20468064Observational study of gene-disease association. (HuGE Navigator)2010-06-30
20602615Observational study of gene-disease association. (HuGE Navigator)2010-09-15
20797317Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)2010-09-15
23900445Variations in genes AGRP, CPE, GHRL, GLP1R, HTR2A, NPY1R, NPY5R, SOCS3 and STAT3 showed modest associations with BMI in European Americans.2015-02-07
23932937these data highlight a novel mechanism by which NPY may promote breast cancer progression, and further implicate a pathological role of the NPY Y5R.2014-05-24
25132261NPY5R is an inducible pro-survival factor that is responsible for chemoresistance in neuroblastoma cells.2015-08-29
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
NPY5R_HUMANIPR000276GO:0004930FamilyG protein-coupled receptor, rhodopsin-likeMolecular FunctionG-protein coupled receptor activity
NPY5R_HUMANIPR000276GO:0007186FamilyG protein-coupled receptor, rhodopsin-likeBiological ProcessG-protein coupled receptor signaling pathway
NPY5R_HUMANIPR000276GO:0016021FamilyG protein-coupled receptor, rhodopsin-likeCellular Componentintegral to membrane
NPY5R_HUMANIPR000393GO:0004983FamilyNeuropeptide Y5 receptorMolecular Functionneuropeptide Y receptor activity
NPY5R_HUMANIPR000393GO:0007186FamilyNeuropeptide Y5 receptorBiological ProcessG-protein coupled receptor signaling pathway
NPY5R_HUMANIPR000393GO:0016021FamilyNeuropeptide Y5 receptorCellular Componentintegral to membrane
NPY5R_HUMANIPR000611GO:0004983FamilyNeuropeptide Y receptor familyMolecular Functionneuropeptide Y receptor activity
NPY5R_HUMANIPR000611GO:0007186FamilyNeuropeptide Y receptor familyBiological ProcessG-protein coupled receptor signaling pathway
NPY5R_HUMANIPR000611GO:0016021FamilyNeuropeptide Y receptor familyCellular Componentintegral to membrane
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

KEGG Pathways

Pathway IDDatabase NamePathway Name
hsa04080KEGG PATHWAYNeuroactive ligand-receptor interaction
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/Q15761_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


Proteomics DB

Evidence File
/mnt/mpp/ms_data/Q15761_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB