CALN1:Calcium-binding protein 8

Gene Name
Calcium-binding protein 8
Protein ID
Q9BXU9
Chromosome ID
7
HPP Status
2
Protein Name
Calcium-binding protein 8
Synonyms

CaBP8

CABP8

"calcium-binding protein CABP8"

calcium-binding protein 8

Calneuron-1

calcium-binding protein CABP8

calneuron I

Calneuron I

calneuron-1

calneuron 1


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=CALN1 ]
Chromosomal Position
7q11.22 | Start:71779491 End:71779491
Sequence
Q9BXU9.fasta
Description

Entrez Gene Summary for CALN1
This gene encodes a protein with high similarity to the calcium-binding proteins of the calmodulin family. The encoded protein contains two EF-hand domains and potential calcium-binding sites. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Jul 2008)

UniProtKB Summary for CALN1
Function: Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity (By similarity). May play a role in the physiology of neurons and is potentially important in memory and learning

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=CALN1 ]
External IDs
Hgnc ID: 13248 EntrezGene ID: 83698 Ensembl ID: ENSG00000183166
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=CALN1 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
19338761CaBP7 and 8 possess a targeting mechanism that is unique amongst the CaBPs that may contribute to differential functional Ca(2+)-sensing by these family members.2010-01-21
20379614Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)2010-06-30
26116628The protein is most abundant in Purkinje cells of the cerebellum and principal neurons of the cortex and limbic brain whereas no expression in glial cells is apparent.2016-01-16
26163462provide strong evidence that CALN1 is a target of miR-137.2015-10-31
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions


Molecular function

Function Description

Calcium ion binding, negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity, may play a role in the physiology of neurons and is potentially important in memory and learning

Reference
http://www.uniprot.org/uniprot/Q9BXU9
http://www.genecards.org/cgi-bin/carddisp.pl?gene=CALN1
Contributed By
Chromosome 7 Research Group Australia

Localisation


Subcellular

Localization Description

Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane

Cytoplasm, perinuclear region.

Cell membrane; Single-pass type IV membrane protein

Reference
http://www.uniprot.org/uniprot/Q9BXU9#subcellular_location
Contributed By
Chromosome 7 Research Group Australia

Tissue

Localization Description

Overexpression in brain

This gene has expression in 51 organs in 93 developmental stages

Moderate cytoplasmic and/or occasional membranous positivity was displayed in basal layers of squamous epithelium, gall bladder, renal glomeruli, Leydig cells, myocytes and subset of bone marrow poietic cells. Neuropil showed distinct positivity, neuronal cells were moderately stained and a subset of glial cells showed strong immunoreactivity. Remaining normal tissues were weakly stained or negative.

Reference
http://bgee.org/?page=gene&gene_id=ENSG00000183166
http://www.proteinatlas.org/ENSG00000183166-CALN1/tissue
https://genevisible.com/tissues/HS/UniProt/Q9BXU9
Contributed By
Chromosome 7 Research Group Australia

Homologues, Orthologues, Paralogues and Family


Orthologues

Orthologs

cow (Bos Taurus), dog (Canis familiaris), mouse (Mus musculus), chimpanzee (Pan troglodytes), rat (Rattus norvegicus), oppossum (Monodelphis domestica), platypus (Ornithorhynchus anatinus), chicken (Gallus gallus), lizard (Anolis carolinensis), tropical clawed frog (Silurana tropicalis), zebrafish (Danio rerio)

Reference
http://www.genecards.org/cgi-bin/carddisp.pl?gene=CALN1#orthologs
Contributed By
Chromosome 7 Research Group Australia

Paralogues

Paralogs

CABP7, CABP2, CALML3, CALM2, CALM1, CALML5, CABP1, CALM3, CABP5, TNNC2, PVALB

Reference
http://www.genecards.org/cgi-bin/carddisp.pl?gene=CALN1#orthologs
Contributed By
Chromosome 7 Research Group Australia

Family

Domain

The C-terminal transmembrane domain (TMD) is necessary and sufficient for membrane targeting. Contains 2 EF-hand domains.

Identified Families

-

Reference
http://www.uniprot.org/uniprot/Q9BXU9#family_and_domains
Contributed By
Chromosome 7 Research Group Australia

Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidenceCABP8_HUMANCABP8_RAT21921999.5410010121912196E-121429
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
CABP8_HUMANIPR002048GO:0005509DomainEF-hand domainMolecular Functioncalcium ion binding
CABP8_HUMANIPR011992GO:0005509DomainEF-hand domain pairMolecular Functioncalcium ion binding
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications


Showing 1-1 of 1 item.

Post Translational Modifications

Ptm NamePtm SiteEvidence
PhosphorylationY12<p>-</p>

Protein Protein Interactions


Database Name

Uniprot

Database Link

http://www.uniprot.org/uniprot/Q9BXU9#interaction ">http://www.uniprot.org/uniprot/Q9BXU9#interaction



Interaction

Subunit structure with PI4KB

Interacting Partner

Subunit structure interacts with PI4KB. This binding competes with FREQ/NCS1 binding in a calcium-dependent manner

Reference

Manual assertion inferred from sequence similarity.
http://www.uniprot.org/uniprot/Q9BXU9#interaction
Contributed By
Chromosome 7 Research Group Australia
Database Name

BioGRID




Database Link

http://thebiogrid.org/123732 ">http://thebiogrid.org/123732

Interaction

Physical interaction

Interacting Partner

DCAF6


Reference
http://thebiogrid.org/123732
Contributed By
Chromosome 7 Research Group Australia

Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/Q9BXU9_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/Q9BXU9_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Showing 1-1 of 1 item.

Proteomics DB

Evidence File
/mnt/mpp/ms_data/Q9BXU9_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB