HELT:Hairy and enhancer of split-related protein HELT

Gene Name
Hairy and enhancer of split-related protein HELT
Protein ID
A6NFD8
Chromosome ID
4
HPP Status
2
Protein Name
Hairy and enhancer of split-related protein HELT
Synonyms

"HES-like"

Hey-like transcription factor (zebrafish)

Megane bHLH factor

hairy and enhancer of split-related protein HELT

Mgn

HES/HEY-like transcription factor

bHLHb44

Hey-like transcription factor

helt bHLH transcription factor

HCM1228

"megane bHLH factor"

Hey-like transcriptional repressor

HESL

Heslike


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=HELT ]
Chromosomal Position
4q35.1 | Start:185018841 End:185018841
Sequence
A6NFD8.fasta
Description

UniProtKB Summary for HELT
Function: Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGCG-3' (By similarity)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=HELT ]
External IDs
Hgnc ID: 33783 EntrezGene ID: 391723 Ensembl ID: ENSG00000187821
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=HELT ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
15375612identified and characterized human HES-like (HESL), rat hesl, and rainbow trout hesl genes by using bioinformatics2010-01-21
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


Sequence Similarity

Db NameQuery UniSubject UniSequence LengthAlignment LengthIdentityCoverageMismatchesGap OpeningsQuery StartQuery EndSubject StartSubject EndEvalueBit Score
Reviewed non-human mammalian with experimental evidenceHELT_HUMANHELT_MOUSE32727877.3485.022035032762402E-97351
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
HELT_HUMANIPR003650GO:0003677DomainOrangeMolecular FunctionDNA binding
HELT_HUMANIPR011598GO:0046983DomainMyc-type, basic helix-loop-helix (bHLH) domainMolecular Functionprotein dimerization activity
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/A6NFD8_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


Proteomics DB

Evidence File
/mnt/mpp/ms_data/A6NFD8_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB