AQP8:Aquaporin-8

Gene Name
Aquaporin-8
Protein ID
O94778
Chromosome ID
16
HPP Status
2
Protein Name
Aquaporin-8
Synonyms

aquaporin 8

AQP-8

aquaporin-8


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=AQP8 ]
Chromosomal Position
16p12.1 | Start:25215731 End:25215731
Sequence
O94778.fasta
Description

Entrez Gene Summary for AQP8
Aquaporin 8 (AQP8) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 8 mRNA is found in pancreas and colon but not other tissues. (provided by RefSeq, Jul 2008)

UniProtKB Summary for AQP8
Function: Forms a water-specific channel; mercury-sensitive. Not permeable to glycerol or urea

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=AQP8 ]
External IDs
Hgnc ID: 642 EntrezGene ID: 343 Ensembl ID: ENSG00000103375
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=AQP8 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
9325099The crystal structure of deoxyhemoglobin S, 2HBS, demonstrates the interaction of the mutant valine with another hemoglobin tetramer and provides insights into formation of the intracellular sickle cell fiber.2004-08-09
11231887Aquaporin 8 is expressed in colonic epithelial cells but was not detected in colorectal tumors.2010-01-21
12712100expression of aquaporin 8 water channel in and up-regulation by second messenger cyclic adenosine monophosphate. Aquaporin 8 messenger RNA has relatively short biologic half-life in vitro.2010-01-21
17461471Upregulation of AQP8 in the colon of ulcerative colitis patients represents a secondary phenomenon which may disturb the physiologic colonic mucus barrier and thus lead to chronic inflammation and ulceration.2010-01-21
17545093Data show that AQP-1, 3, 8, 9 mRNA expression was detected in both amnion and chorion and can be associated with intramembranous transport and volume regulation of amniotic fluid.2010-08-23
18788571The expression of AQP8 protein is positively correlated with bcl-2 protein in human cervical carcinoma.2011-10-29
18948439Knockdown of hepatocyte aquaporin-8 by RNA interference induces defective bile canalicular water transport.2010-01-21
19087520With the increase of cAMP, AQP8 mRNA and protein expressions significantly increased in WISH cells in vitro.2011-12-03
19563057The expression of AQP8 mRNA and protein is significantly increased in the amnion and placenta of polyhydramnios, suggesting that AQP8 may play an important role in the regulation of amniotic fluid volume.2011-08-20
20144166Aquaporin 8 has a role in intramembranous water transport and the balance of amniotic fluid.2010-05-31
20424473Observational study of gene-disease association. (HuGE Navigator)2010-06-30
20732771When polyhydramnios occurs, expression of aquaporin 8 and aquaporin 9 in fetal membranes and placenta is an adaptive change.2011-02-26
22192778Reconstitution of water channel function and 2D-crystallization of human aquaporin 8.2012-04-28
22901156AQP8 expression significantly increased in advanced stage of cervical cancer, deeper infiltration, metastatic lymph nodes and larger tumor volume.2013-01-26
23595390AQP8 and its relationship with miRNAs may be involved in the pathogenesis of Ulcerative colitis (UC).2014-06-28
23679281High Aquaporin 8 expression is associated with invasion of cervical cancer.2014-01-11
23953589AQP8 has a role in the pathogenesis of PCOS.2014-06-14
24055034The expression levels and immunoreactive score of AQP8 protein and mRNA increased in low-grade astrocytomas, and further increased in high-grade astrocytomas, especially in glioblastoma.2013-12-07
24415197mtAQP8 knockdown induces necrotic cell death in human neoplastic hepatic cells, a finding that might be relevant to therapeutic strategies against hepatoma cells.2014-11-22
24440277the results here reported indicate that AQP8 is able to modulate H2O2 transport through the plasma membrane affecting redox signalling linked to leukaemia cell proliferation2014-04-26
25120769increased AQP8, Erk1/2 and phosphorylated-Erk1/2 expression may play a role in transformation of cervical intraepithelila neoplasia into cervical cancer, and in early invasion and lymphatic metastasis of cervical cancer2015-05-16
25550802EGF induces AQP8 expression and cell migration in Eca-109 cells via the EGFR/Erk1/2 signal transduction pathway.2015-09-05
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation



Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




Showing 1-20 of 36 items.

gpmDB

Peptide SequenceEvidence LevelLog ENumber Of ObservationSpectraAccession IDProteotypicityAnnotation
SGEIAMCEPEFGNDKgreen-12.4211ENSP00000219660Proteotypic
SGEIAMCEPEFGNDKgreen-12.4211ENSP00000219660Proteotypic
SGEIAMCEPEFGNDKgreen-10.3211ENSP00000219660Proteotypic
SGEIAMCEPEFGNDKgreen-10.3211ENSP00000219660Proteotypic
SGEIAMCEPEFGNDKgreen-10.3211ENSP00000219660Proteotypic
SGEIAMCEPEFGNDKgreen-10.3211ENSP00000219660Proteotypic
SGEIAMCEPEFGNDKgreen-9.7211ENSP00000219660Proteotypic
SGEIAMCEPEFGNDKgreen-9.7211ENSP00000219660Proteotypic
SGEIAMCEPEFGNDKgreen-9.2211ENSP00000219660Proteotypic
SGEIAMCEPEFGNDKgreen-9.2211ENSP00000219660Proteotypic
SGEIAMCEPEFGNDKARgreen-9.121ENSP00000219660Proteotypic
SGEIAMCEPEFGNDKARgreen-9.121ENSP00000219660Proteotypic
SGEIAMCEPEFGNDKgreen-8.8211ENSP00000219660Proteotypic
SGEIAMCEPEFGNDKgreen-8.8211ENSP00000219660Proteotypic
SGEIAMCEPEFGNDKgreen-8.1211ENSP00000219660Proteotypic
SGEIAMCEPEFGNDKARgreen-8.121ENSP00000219660Proteotypic
SGEIAMCEPEFGNDKgreen-8.1211ENSP00000219660Proteotypic
SGEIAMCEPEFGNDKARgreen-8.121ENSP00000219660Proteotypic
SGEIAMCEPEFGNDKgreen-7.9211ENSP00000219660Proteotypic
SGEIAMCEPEFGNDKgreen-7.9211ENSP00000219660Proteotypic
Evidence File
/mnt/mpp/ms_data/O94778_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


PRIDE

Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
/mnt/mpp/ms_data/O94778_pridedb.txt
Reference
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456.
https://www.ebi.ac.uk/pride/archive/ ">PRIDE Archive


Showing 1-3 of 3 items.

Proteomics DB

Peptide SequenceSearch EngineScoreThreshold ScoreIdentification IDExperiment IDAnnotation
AREPSVGGRMaxquant151.790245295224272
AREPSVGGRMaxquant128.540244738280273
AREPSVGGRMaxquant126.190245295228272
Evidence File
/mnt/mpp/ms_data/O94778_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB