CLDN22:Claudin-22

Gene Name
Claudin-22
Protein ID
Q8N7P3
Chromosome ID
4
HPP Status
2
Protein Name
Claudin-22
Synonyms

claudin-22

claudin 22

CLDN21


[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=CLDN22 ]
Chromosomal Position
4q35.1 | Start:183318194 End:183318194
Sequence
Q8N7P3.fasta
Description

Entrez Gene Summary for CLDN22
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and overlaps the 3' UTR of the WWC2 gene (GeneID: 80014) on the opposite strand. (provided by RefSeq, Aug 2010)

UniProtKB Summary for CLDN22
Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity (By similarity)

[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=CLDN22 ]
External IDs
Hgnc ID: 2044 EntrezGene ID: 53842 Ensembl ID: ENSG00000177300
[Reference: http://www.genecards.org/cgi-bin/carddisp.pl?gene=CLDN22 ]
Reference Source
http://www.nextprot.org

Gene Reference Into Function (GeneRIF)


PubMed IDGeneRIF TextLast Update
12736707CLDN21, clustered with CLDN22 at human chromosome 4q35.1, is a four-transmembrane protein with WWCC motif, defined by W-X(17-22)-W-X(2)-C-X(8-10)-C.2003-12-03
Reference
http://www.ncbi.nlm.nih.gov/gene/about-generif
ftp://ftp.ncbi.nih.gov/gene/GeneRIF/

OMICSDI Browser



Relevant citations within the PubMed literature

         

Putative/known Functions



Localisation



Homologues, Orthologues, Paralogues and Family



Sequence Similarity and Functional Annotation


InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
CLD22_HUMANIPR004031GO:0016021FamilyPMP-22/EMP/MP20/Claudin superfamilyCellular Componentintegral to membrane
CLD22_HUMANIPR006187GO:0005198FamilyClaudinMolecular Functionstructural molecule activity
CLD22_HUMANIPR006187GO:0005923FamilyClaudinCellular Componenttight junction
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

KEGG Pathways

Pathway IDDatabase NamePathway Name
hsa04514KEGG PATHWAYCell adhesion molecules (CAMs)
hsa04530KEGG PATHWAYTight junction
hsa04670KEGG PATHWAYLeukocyte transendothelial migration
hsa05160KEGG PATHWAYHepatitis C
Reference
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications



Protein Protein Interactions



Best Available Mass Spectra without FDR




gpmDB

Evidence File
/mnt/mpp/ms_data/Q8N7P3_gpmdb.txt
Reference
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803.
http://gpmdb.thegpm.org/ ">Global Proteome Machine Database - THE GPM


Proteomics DB

Evidence File
/mnt/mpp/ms_data/Q8N7P3_protdb.txt
Reference
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7.
https://www.proteomicsdb.org/ ">Proteomics DB