ADAMTS6:A disintegrin and metalloproteinase with thrombospondin motifs 6

Gene Name
A disintegrin and metalloproteinase with thrombospondin motifs 6
Protein ID
Chromosome ID
HPP Status
Protein Name
A disintegrin and metalloproteinase with thrombospondin motifs 6



ADAM metallopeptidase with thrombospondin type 1 motif, 6


A disintegrin and metalloproteinase with thrombospondin motifs 6

"a disintegrin and metalloproteinase with thrombospondin motifs 6"

a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 6

EC 3.4.24.-

[Reference: ]
Chromosomal Position
5q12.3 | Start:65148736 End:65148736

Entrez Gene Summary for ADAMTS6
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. (provided by RefSeq, Jul 2008)

[Reference: ]
External IDs
Hgnc ID: 222 EntrezGene ID: 11174 Ensembl ID: ENSG00000049192
[Reference: ]
Reference Source

Gene Reference Into Function (GeneRIF)

PubMed IDGeneRIF TextLast Update
16129570Study shows that the ADAMTS6 transcript contains unusually large untranslated regions (UTRs) at both the 5' and 3'end, and the 5'UTR contains 11 AUG codons upstream of the predicted ADAMTS6 start codon.2010-01-21
18579725The gain of function studies indicated that ADAM metallopeptidase with thrombospondin type 1 motif 6 activate NR5A1 gene expression.2010-01-21
20379614Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)2010-06-30
26686553Novel inguinal hernia susceptibility genes are identified as EFEMP1, WT1, EBF2 and ADAMTS6.2016-05-14


Relevant citations within the PubMed literature


Putative/known Functions


Homologues, Orthologues, Paralogues and Family

Sequence Similarity and Functional Annotation

InterProScan Annotation

Uniprot IDInterpro IDGo IDTypeNameCategoryDescription
ATS6_HUMANIPR001590GO:0004222DomainPeptidase M12B, ADAM/reprolysinMolecular Functionmetalloendopeptidase activity
ATS6_HUMANIPR001590GO:0006508DomainPeptidase M12B, ADAM/reprolysinBiological Processproteolysis
ATS6_HUMANIPR002870GO:0004222DomainPeptidase M12B, propeptideMolecular Functionmetalloendopeptidase activity
ATS6_HUMANIPR002870GO:0006508DomainPeptidase M12B, propeptideBiological Processproteolysis
ATS6_HUMANIPR002870GO:0008270DomainPeptidase M12B, propeptideMolecular Functionzinc ion binding
ATS6_HUMANIPR010294GO:0004222DomainADAM-TS Spacer 1Molecular Functionmetalloendopeptidase activity
ATS6_HUMANIPR010294GO:0031012DomainADAM-TS Spacer 1Cellular Componentextracellular matrix
ATS6_HUMANIPR010909GO:0008233DomainPLACMolecular Functionpeptidase activity
ATS6_HUMANIPR013273GO:0005578FamilyPeptidase M12B, ADAM-TSCellular Componentproteinaceous extracellular matrix
ATS6_HUMANIPR013273GO:0008237FamilyPeptidase M12B, ADAM-TSMolecular Functionmetallopeptidase activity
ATS6_HUMANIPR013273GO:0008270FamilyPeptidase M12B, ADAM-TSMolecular Functionzinc ion binding
ATS6_HUMANIPR024079GO:0008237DomainMetallopeptidase, catalytic domainMolecular Functionmetallopeptidase activity
Islam MT, Garg G, Hancock WS, Risk BA, Baker MS, Ranganathan S (2014) Protannotator: A Semiautomated Pipeline for Chromosome-Wise Functional Annotation of the "Missing" Human Proteome. J Proteome Res. 13, 76-83.

Post Translational Modifications

Protein Protein Interactions

Best Available Mass Spectra without FDR


Evidence File
Fenyö, David; Beavis, Ronald C. (2015). "The GPMDB REST interface". Bioinformatics 31 (12): 2056–2058. doi:10.1093/bioinformatics/btv107. ISSN 1367-4803. ">Global Proteome Machine Database - THE GPM


Peptide SequenceScoresPride IDSpectrum IDAnnotation
No results found.
Evidence File
Vizcaino JA, et al. 2016 update of the PRIDE database and related tools. Nucleic Acids Res. 2016 Jan 1;44(D1):D447-D456. ">PRIDE Archive

Proteomics DB

Evidence File
Wilhelm, M et al. (2014) Mass-spectrometry-based draft of the human proteome. Nature. 509:582-7. ">Proteomics DB